Микродиализ: возможности и перспективы метода при трансплантации печени (обзор)

Оценка качества донорского органа и начальной функции трансплантата имеет принципиальное значение, особенно при пересадке печени. Исследования последних лет показали возможность использования микродиализа для мониторинга состояния энергетического обмена в пересаженных почке и печени. Этот метод позволяет определять концентрации веществ, растворенных во внеклеточной жидкости трансплантата, и регистрировать их изменения еще до того, как это отразится на показателях периферической крови. В настоящее время наиболее часто микродиализ применяется в неврологии и нейрохирургии для оценки объема и тяжести повреждения вещества головного мозга. Использование метода для изучения механизмов ишемического и реперфузионного повреждения трансплантата и процессов, протекающих при развитии его ранней дисфункции, представляется перспективным направлением исследований.

В данном обзоре представлены результаты экспериментальных и клинических работ, обсуждаются целесообразность и перспективы микродиализного мониторинга при трансплантации печени.

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