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Метаболизм экстрацеллюлярного матрикса при бронхиальной астме (обзор)

Метаболизм экстрацеллюлярного матрикса при бронхиальной астме (обзор)

Т.И. Елисеева, Е.В. Туш, С.В. Красильникова, С.В. Кузнецова, Р.А. Ларин, Н.И. Кубышева, О.В. Халецкая, Т.Е. Потемина, С.В. Рязанцев, С.К. Игнатов,
Ключевые слова: бронхиальная астма; аллергический ринит; хронический риносинусит; экстрацеллюлярный матрикс; ремоделирование.
2018, том 10, номер 4, стр. 220.
DOI: https://doi.org/10.17691/stm2018.10.4.25

Полный текст статьи

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Бронхиальная астма ассоциирована с патологией верхних дыхательных путей (ВДП), прежде всего с аллергическим ринитом, который, в свою очередь, чаще наблюдается в комбинации с другими патологическими состояниями ВДП, включая процессы гиперплазии слизистой оболочки полости носа. Наличие хронического риносинусита является предиктором более тяжелого течения астмы.

Важныq компонент патогенеза данных болезней — ремоделирование (перестройка) экстрацеллюлярного матрикса и смежных структур ВДП, что приводит к утяжелению течения болезней и ригидности к терапии. Известно, что ремоделирование нижних дыхательных путей при бронхиальной астме характеризуется эпителиальным слущиванием, гиперплазией бокаловидных клеток, утолщением базальной мембраны, субэпителиальным фиброзом, гиперплазией гладкомышечной мускулатуры дыхательных путей и повышенным ангиогенезом. В то же время ремоделирование ВДП у пациентов с астмой еще мало изучено, данные пока ограничены и часто противоречат друг другу. При изолированном аллергическом рините процессы ремоделирования не выражены и ограничены, по-видимому, утолщением базальной мембраны. Проявления ремоделирования ВДП при хроническом риносинусите демонстрируют эпителиальную гиперплазию, увеличение осаждения и деградации матрикса наряду с накоплением белков плазмы.

Несмотря на обширные исследования последних лет, точные клеточные и молекулярные механизмы, участвующие в ремоделировании дыхательных путей, остаются не полностью определенными, что требует дальнейшего их изучения. В обзоре рассматриваются также аспекты нейрогуморальной регуляции метаболизма экстрацеллюлярного матрикса и процессов ремоделирования верхних и нижних дыхательных путей у пациентов с бронхиальной астмой.

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Eliseeva Т.I., Tush Е.V., Krasilnikova S.V., Kuznetsova S.V., Larin R.A., Kubysheva N.I., Khaletskaya О.V., Potemina T.E., Ryazantsev S.V., Ignatov S.K. Metabolism of the Extracellular Matrix in Bronchial Asthma (Review). Sovremennye tehnologii v medicine 2018; 10(4): 220, https://doi.org/10.17691/stm2018.10.4.25


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