Возможности блокчейн-технологии в медицине (обзор)

Приводится краткое описание блокчейн-технологии, представляющей собой инструмент для хранения и передачи данных. Показаны современные направления ее развития. Описаны известные на сегодняшний день особенности и преимущества использования блокчейн-технологии в медицине. Проанализированы возможности и перспективы применения блокчейна для решения некоторых задач в здравоохранении. Рассмотрены недостатки и проблемы, возникающие при использовании этой технологии в здравоохранении.

Авторы резюмируют, что большинство проектов по применению блокчейна в медицине находятся в данный момент на стадии разработки. Вместе с тем на сегодняшний день уже реализовано достаточно много проектов, появились медицинские приложения на блокчейне. Междисциплинарный подход и сотрудничество врачей с блокчейн-специалистами даст возможность медицине по максимуму использовать бурно растущие цифровые технологии.

1. Nakamoto S. Bitcoin: a peer-to-peer electronic cash system. URL: https://bitcoin.org/bitcoin.pdf.
2. Савельев И.Е. Технология blockchain и ее применение. Прикладная информатика 2016; 11(6): 19–24.
3. Свон М. Блокчейн: схема новой экономики. М: Олимп-Бизнес; 2016; 224 c.
4. Collins R. Blockchain: a new architecture for digital content. EContent 2016; 39(8): 22–23.
5. Chung M., Kim J. The internet information and technology research directions based on the fourth industrial revolution. KSII Transactions on Internet and Information Systems 2016; 10(3): 1311–1320, https://doi.org/10.3837/tiis.2016.03.020.
6. Underwood S. Blockchain beyond bitcoin. Commun ACM 2016; 59(11): 15–17, https://doi.org/10.1145/2994581.
7. Yli-Huumo J., Ko D., Choi S., Park S., Smolander K. Where is current research on blockchain technology? — A systematic review. PLoS One 2016; 11(10), e0163477, https://doi.org/10.1371/journal.pone.0163477.
8. Agbo C.C., Mahmoud Q.H., Eklund J.M. Blockchain technology in healthcare: a systematic review. Healthcare 2019; 7(2): 56, https://doi.org/10.3390/healthcare7020056.
9. Crosby M., Nachiappan, Pattanayak P., Verma S., Kalyanaraman V. Blockchain technology: beyond bitcoin. Applied Innovation Review 2016; 2: 6–10.
10. Taylor P.J., Dargahi T., Dehghantanha A., Parizi R.M., Choo K.-K.R. A systematic literature review of blockchain cyber security. Digital Communications and Networks 2019, https://doi.org/10.1016/j.dcan.2019.01.005.
11. Zhang Y., Wen J. The IoT electric business model: using blockchain technology for the internet of things. Peer-to-Peer Networking and Applications 2017; 10(4): 983–994, https://doi.org/10.1007/s12083-016-0456-1.
12. Могайар У., Бутерин В. Блокчейн для бизнеса. М: Эксмо; 2017: 224 c.
13. Красикова Е.М. Вlockchain: технология будущего. Аллея науки 2018; 1(1): 219–224.
14. Садуллаев Х.Х.У. Семь конструктивных принципов экономики на блокчейне. Аллея науки 2018; 3(1): 911–913.
15. Melnychenko O., Hartinger R. Role of blockchain technology in accounting and auditing. European Cooperation 2017; 9(28): 27–34.
16. Knezevic D. Impact of blockchain technology platform in changing the financial sector and other industries. Montenegrin Journal of Economics 2018; 14(1): 109–120, https://doi.org/10.14254/1800-5845/2018.14-1.8.
17. Biktimirov M.R., Domashev A.V., Cherkashin P.A., Shcherbakov A.Y. Blockchain technology: universal structure and requirements. Automatic Documentation and Mathematical Linguistics 2017; 51(6): 235–238, https://doi.org/10.3103/s0005105517060036.
18. Pilkington M. Blockchain technology: principles and applications. In: Olleros F.X., Zhegu M. (editors). Research handbook on digital transformations. Edward Elgar Publishing; 2016; p. 225–253, https://doi.org/10.4337/9781784717766.00019.
19. Tapscott D., Tapscott A. Blockchain revolution: how the technology behind bitcoin is changing money, business, and the world. New York: Penguin; 2016; 386 p.
20. Sharples M., Domingue J. A distributed system for educational record, reputation and reward. In: Adaptive and adaptable learning. Springer, Cham; 2016; p. 490–496, https://doi.org/10.1007/978-3-319-45153-4_48.
21. Часовских В.П., Лабунец В.Г., Воронов М.П. Технология “блокчейн” (blockchain) в образовании вузов и цифровой экономике. Эко-потенциал 2017; 2(18): 99–105.
22. Skiba D.J. The potential of blockchain in education and health care. Nursing education perspectives 2017; 38(4): 220–221, https://doi.org/10.1097/01.nep.0000000000000190.
23. Hoy M.B. An introduction to the blockchain and its implications for libraries and medicine. Medical reference services quarterly 2017; 36(3): 273–279, https://doi.org/10.1080/02763869.2017.1332261.
24. De la Rosa J., Torres-Padrosa V., El-Fakdi A., Gibovic D., Hornyák O., Maicher L., Miralles F. A survey of blockchain technologies for open innovation. In: Proceedings of the 4rd Annual World Open Innovation Conference, WOIC 2017. San Francisco, USA; 2017. URL: http://eia.udg.edu/~aelfakdi/papers/woic17.pdf.
25. Tao X. Research on the development and significance of “Blockchain+” education. Journal of Distance Education 2017; 2: 003.
26. Dettling W. How to teach blockchain in a business school. In: Business information systems and technology 4.0. Springer, Cham; 2018; p. 213–225, https://doi.org/10.1007/978-3-319-74322-6_14.
27. Gaetani E., Aniello L., Baldoni R., Lombardi F., Margheri A., Sassone V. Blockchain-based database to ensure data integrity in cloud computing environments. In: Proceedings of the First Italian Conference on Cybersecurity (ITASEC17). Venice, Italy; 2017; p. 146–155. URL: http://ceur-ws.org/Vol-1816/paper-15.pdf.
28. Rimba P., Tran A.B., Weber I., Staples M., Ponomarev A., Xu X. Comparing blockchain and cloud services for business process execution. In: IEEE International Conference on Software Architecture, ICSA 2017. Gothenburg, Sweden; 2017; p. 257–260, https://doi.org/10.1109/icsa.2017.44.
29. Kshetri N. Can blockchain strengthen the internet of things? IT Professional 2017; 19(4): 68–72, https://doi.org/10.1109/mitp.2017.3051335.
30. Ayed A.B. A conceptual secure blockchain-based electronic voting system. International Journal of Network Security & Its Applications 2017; 9(3): 1–9, https://doi.org/10.5121/ijnsa.2017.9301.
31. Lee K., James J.I., Ejeta T.G., Kim H.J. Electronic voting service using block-chain. Journal of Digital Forensics, Security and Law 2016; 11(2), https://doi.org/10.15394/jdfsl.2016.1383.
32. Noizat P. Blockchain electronic vote. In: Chuen D.L.K. (editor). Handbook of digital currency. Bitcoin, innovation, financial instruments, and big data. Elsevier; 2015; p. 453–461, https://doi.org/10.1016/b978-0-12-802117-0.00022-9.
33. Shrier D., Wu W., Pentland A. Blockchain & infrastructure (identity, data security). Massachusetts Institute of Technology, MIT Connection Science; 2016. URL: https://www.getsmarter.com/blog/wp-content/uploads/2017/07/mit_blockchain_and_infrastructure_report.pdf.
34. Zeilinger M. Digital art as “Monetised Graphics”: enforcing intellectual property on the blockchain. Philosophy & Technology 2018; 31(1): 15–41, https://doi.org/10.1007/s13347-016-0243-1.
35. Tsai W.T., Feng L., Zhang H., You Y., Wang L., Zhong Y. Intellectual-property blockchain-based protection model for microfilms. In: IEEE International Symposium on Service-Oriented System Engineering (SOSE). San Francisco, USA; 2017; p. 174–178, https://doi.org/10.1109/sose.2017.35.
36. Блокчейн. URL: https://ru.wikipedia.org/wiki/Блокчейн.
37. Онлайн-курс по Blockchain. URL: https://distributedlab.com/online-course.
38. Поппер Н. Цифровое золото. Невероятная история Биткойна, или как идеалисты и бизнесмены изобретают деньги заново. М: Диалектика; 2018; 368 c.
39. Винья П., Кейси М. Эпоха криптовалют. Как биткоин и блокчейн меняют мировой экономический порядок. М: Манн, Иванов и Фербер; 2017; 432 c.
40. Рикардс Д. Золотой запас. Почему золото, а не биткоины — валюта XXI века? М: Эксмо; 2017; 192 c.
41. Равал С. Децентрализованные приложения. Техно­логия blockchain в действии. СПб: Питер; 2017; 240 c.
42. Antonopoulos A.M. The Internet of money. Merkle Bloom LLC; 2016; 150 p.
43. Champagne P. The book of Satoshi: the collected writings of bitcoin creator Satoshi Nakamoto. USA: e53 Publishing LLC; 2014; 394 p.
44. Mannaro К., Pinna А., Marchesi М. Crypto-trading: blockchain-oriented energy market. In: AEIT International Annual Conference. Cagliari, Italy; 2017, https://doi.org/10.23919/aeit.2017.8240547.
45. Акулич М. Blockchain для маркетинга. 2019. URL: https://fictionbook.ru/author/margarita_akulich/blockchain_dlya_marketinga/read_online.html.
46. Sikorski J.J., Haughton J., Kraft M. Blockchain technology in the chemical industry: machine-to-machine electricity market. Applied Energy 2017; 195: 234–246, https://doi.org/10.1016/j.apenergy.2017.03.039.
47. Заславский А.А. Перспективы использования алго­ритмов блокчейн для обеспечения безопасности при управ­лении образовательной организацией. Вестник Российского университета дружбы народов. Серия: Информатизация образования 2018; 15(1): 101–106, https://doi.org/10.22363/2312-8631-2018-15-1-101-106.
48. Borioli G.S., Couturier J. How blockchain technology can improve the outcomes of clinical trials. British Journal of Healthcare Management 2018; 24(3): 156–162, https://doi.org/10.12968/bjhc.2018.24.3.156.
49. Roman-Belmonte J.M., De la Corte-Rodriguez H., Rodriguez-Merchan E.C. How blockchain technology can change medicine. Postgrad Med 2018; 130(4): 420–427, https://doi.org/10.1080/00325481.2018.1472996.
50. Hoy M.B. An introduction to the blockchain and its implications for libraries and medicine. Med Ref Serv Q 2017; 36(3): 273–279, https://doi.org/10.1080/02763869.2017.1332261.
51. Dubovitskaya A., Xu Z., Ryu S., Schumacher M., Wang F. How blockchain could empower e-health: an application for radiation oncology. In: Begoli E., Wang F., Luo G. (editors). Data management and analytics for medicine and healthcare. DMAH 2017. Lecture notes in computer science. Springer, Cham; 2017; p. 3–6, https://doi.org/10.1007/978-3-319-67186-4_1.
52. Rabah K. Challenges & opportunities for blockchain powered healthcare systems. A review. Mara Research Journal of Medicine & Health Sciences 2017; 1(1): 45–52.
53. Liu P.T.S. Medical record system using blockchain, big data and tokenization. In: Lam K.-Y., Chi C.-H., Qing S. (editors). Information and communications security. ICICS 2016. Lecture notes in computer science. Springer, Cham; 2016; p. 254–261, https://doi.org/10.1007/978-3-319-50011-9_20.
54. Dubovitskaya A., Novotny P., Xu Z., Wang F. Applications of blockchain technology for data-sharing in oncology: results from a systematic literature review. Oncology 2019; 3: 1–9, https://doi.org/10.1159/000504325.
55. Huckle S., Bhattacharya R., White M., Beloff N. Internet of things. Blockchain and shared economy applications. Procedia Computer Science 2016; 98: 461–466, https://doi.org/10.1016/j.procs.2016.09.074.
56. Куликов Н.И., Кудрявцева Ю.В. Банки на поро­ге новой технологической революции. Вопросы совре­менной науки и практики 2017; 2(64): 69–78.
57. Pazaitis A., De Filippi P., Kostakis V. Blockchain and value systems in the sharing economy: the illustrative case of backfeed. Technological Forecasting and Social Change 2017; 125: 105–115, https://doi.org/10.1016/j.techfore.2017.05.025.
58. Alexandrikova I., Kozlova E. Bitcoin as a new instrument of financial services. Teoriya i praktika sovremennoy nauki 2017; 6(24): 48–51.
59. Лелу Л. Блокчейн от А до Я: все о технологии десятилетия. М: Бомбора; 2018; 256 c.
60. Дрешер Д. Основы блокчейна. М: ДМК Пресс; 2018; 312 c.
61. Попов В. Блокчейн философия. 2018. URL: https://www.litres.ru/vladimir-popov-7629101/blokcheyn-filosofiya-chast-i.
62. Shuaib K., Saleous H., Shuaib K., Zaki N. Blockchains for secure digitized medicine. J Pers Med 2019; 9(3): 35, https://doi.org/10.3390/jpm9030035.
63. Kraft D. Difficulty control for blockchain-based consensus systems. Peer-to-Peer Networking and Applications 2016; 9(2): 397–413, https://doi.org/10.1007/s12083-015-0347-x.
64. Kuo T.T., Kim H.E., Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. J Am Med Inform Assoc 2017; 24(6): 1211–1220, https://doi.org/10.1093/jamia/ocx068.
65. Telegram open network. URL: https://ru.ton-telegram.net/.
66. Dannen C. Introducing Ethereum and Solidity. Foundations of cryptocurrency and blockchain programming for beginners. New York, Apress; 2017; 185 p., https://doi.org/10.1007/978-1-4842-2535-6.
67. Diedrich H. Ethereum: blockchains, digital assets, smart contracts, decentralized autonomous organizations. Create Space Independent Publishing Platform; 2016; 360 p.
68. Цыганов С.Н., Туголукова А.В. Возможности при­ме­нения технологии блокчейн в здравоохранении. В кн.: Перспективы развития науки и образования. М: ИП Туголуков А.В.; 2017; c. 123–126.
69. URL: https://vademec.ru/news/2017/09/06/elektronnye-meditsinskie-karty-rossiyan-budut-khranit-po-printsipu-blokcheyn/.
70. Блокчейн для электронных медицинских карт. URL: https://medicalchain.com/ru/.
71. BurstIQ Receives Frost & Sullivan 2019 Best Practice Award for Healthcare Data Management. URL: https://finance.yahoo.com/news/burstiq-receives-frost-sullivan-2019-133000808.html.
72. Roehrs A., da Costa С.A., da Rosa Righi R. OmniPHR: a distributed architecture model to integrate personal health records. J Biomed Inform 2017; 71: 70–81, https://doi.org/10.1016/j.jbi.2017.05.012.
73. Yoon H.J. Blockchain technology and healthcare. Healthcare Informatics Research 2019; 25(2): 59–60, https://doi.org/10.4258/hir.2019.25.2.59.
74. Azaria A., Ekblaw A., Vieira T., Lippman A. MedRec: using blockchain for medical data access and permission management. In: International Conference on Open and Big Data (OBD). Vienna, Austria; 2016, https://doi.org/10.1109/obd.2016.11.
75. Trust, confidence and verifiable data audit. URL: https://deepmind.com/blog/trust-confidence-verifiable-data-audit/.
76. Doc.ai. URL: https://doc.ai.
77. Open Longevity. Клинические исследования по ини­циативе пациентов. Klinicheskie issledovaniya po initsiative patsientov [Clinical trials initiated by patients]. URL: https://medium.com/open-longevity/.
78. Robomed. URL: https://robo-med.com.
79. Doctor Smart. URL: http://doctorsmart.vc/ru.
80. Биоритм-браслет. URL: https://www.tokendesk.io/ico/bioritmai.
81. Zenome. A first decentralized Internet of genomic data and services. URL: https://zenome.io/.
82. ARNA genomics. URL: https://arna.bio/en/.
83. Benchoufi M., Ravaud P. Blockchain technology for improving clinical research quality. Trials 2017; 18(1): 335, https://doi.org/10.1186/s13063-017-2035-z.
84. Baunm S. Health IT startups working to secure pharma supply chains? URL: http://medcitynews.com/2017/01/drug-supply-chain-security-and-technology/.
85. Hussien H.M., Yasin S.M., Udzir S.N., Zaidan A.A., Zaidan B.B. A systematic review for enabling of develop a blockchain technology in healthcare application: taxonomy, substantially analysis, motivations, challenges, recommendations and future direction. J Med Syst 2019; 43(10): 320, https://doi.org/10.1007/s10916-019-1445-8.
86. Беляев А.М., Стилиди И.С., Каприн А.Д., Личи­ницер М.Р., Мещеряков А.А., Семиглазов В.Ф., Имя­ни­тов Е.Н., Семиглазова Т.Ю., Полторацкий А.Н., Кон­стан­тинов Л.В., Петрусенко И.А., Никитин О.И., За­ха­ров К.А., Трифонов М.И., Плахов Д.Н. Блокчейн в здра­во­охранении: возможности для использования в кли­ни­ческих исследованиях. Лечебное дело 2018; 2: 100–105.
87. Chang M.C., Hsiao M.Y., Boudier-Revéret M. Blockchain technology: efficiently managing medical information in the pain management field. Pain Med 2019, https://doi.org/10.1093/pm/pnz261.
88. Bhattacharya S., Singh A., Hossain M.M. Strengthening public health surveillance through blockchain technology. AIMS Public Health 2019; 6(3): 326–333, https://doi.org/10.3934/publichealth.2019.3.326.
89. Johnson M., Jones M., Shervey M., Dudley J.T., Zimmerman N. Building a secure biomedical data sharing decentralized app (DApp): tutorial. J Med Internet Res 2019; 21(10): e13601, https://doi.org/10.2196/13601.
90. Balis C., Tagopoulos I., Dimola K. Moving towards a blockchain-based healthcare information system. Stud Health Technol Inform 2019; 262: 168–171, https://doi.org/10.3233/SHTI190044.
91. Mackey T.K., Kuo T.T., Gummadi B., Clauson K.A., Church G., Grishin D., Obbad K., Barkovich R., Palombini M. ‘Fit-for-purpose?’ — challenges and opportunities for applications of blockchain technology in the future of healthcare. BMC Med 2019; 17(1): 68, https://doi.org/10.1186/s12916-019-1296-7.
92. Kuo T.T., Zavaleta Rojas H., Ohno-Machado L. Comparison of blockchain platforms: a systematic review and healthcare examples. J Am Med Inform Assoc 2019; 26(5): 462–478, https://doi.org/10.1093/jamia/ocy185.
93. Drosatos G., Kaldoudi E. Blockchain applications in the biomedical domain: a scoping review. Comput Struct Biotechnol J 2019; 17: 229–240, https://doi.org/10.1016/j.csbj.2019.01.010.
94. Литвин А.А., Литвин В.А. Системы поддержки принятия решений в хирургии. Новости хирургии 2014; 22(1): 96–100.
95. Clinical decision support: the road ahead. Greenes R.A. (editor). Boston: Elsevier Academic Press; 2007; 581 p.
96. O’Donoghue O., Vazirani A.A., Brindley D., Meinert E. Design choices and trade-offs in health care blockchain implementations: systematic review. J Med Internet Res 2019; 21(5): e12426, https://doi.org/10.2196/12426.
97. Кобринский Б.А. Системы поддержки принятия ре­­ше­ний в здравоохранении и обучении. Врач и инфор­мационные технологии 2010; 2: 39–45.
98. Krittanawong C., Rogers A.J., Aydar M., Choi E., Johnson K.W., Wang Z., Narayan S.M. Integrating blockchain technology with artificial intelligence for cardiovascular medicine. Nat Rev Cardiol 2019, https://doi.org/10.1038/s41569-019-0294-y.
99. Mamoshina P. Ojomoko L., Yanovich Y., Ostrovski A., Botezatu A., Prikhodko P., Izumchenko E., Aliper A., Romantsov K., Zhebrak A., Ogu I.O., Zhavoronkov A. Converging blockchain and next-generation artificial intelligence technologies to decentralize and accelerate biomedical research and healthcare. Oncotarget 2018; 9(5): 5665–5690, https://doi.org/10.18632/oncotarget.22345.

Litvin А.А., Korenev S.V., Knyazeva Е.G., Litvin V. The Possibilities of Blockchain Technology in Medicine (Review). Sovremennye tehnologii v medicine 2019; 11(4): 191, https://doi.org/10.17691/stm2019.11.4.21