Влияние муколитических агентов N-ацетилцистеина и эрдостеина на гемостаз у людей
Есть лишь несколько исследований на животных и людях, в которых сообщается, что муколитические агенты N-ацетилцистеин и эрдостеин оказывают разрушительное воздействие на каскад коагуляции.
Цель исследования — изучение влияния эрдостеина и N-ацетилцистеина на коагуляционный путь.
Материалы и методы. Исследование проведено на пациентах, получавших N-ацетилцистеин (600 мг/день) или эрдостеин (600 мг/день) в течение 7–14 дней. Для оценки параметров коагуляции и гемограммы взяты образцы венозной крови до начала лечения и на 7–14-й дни после.
Результаты. У пациентов, получавших эрдостеин, уровни фактора II значительно снизились, а количество тромбоцитов значительно увеличилось. У пациентов, получавших N-ацетилцистеин, уровни D-димера снизились, а уровни фактора VII увеличились, однако эти изменения не были статистически значимыми (p=0,069 и p=0,062 соответственно). Другие параметры коагуляции и гемограммы не изменились в обеих группах. Таким образом, эрдостеин может оказывать двойственное влияние на каскад коагуляции через свои различные метаболиты.
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