Influence of the New Derivatives of a 3-hydroxyperidine on the Protein Peroxidation Process
Aim of investigation is a study of the new 3-oxypyridine (3-OP): 3-OP of oxalate, 3-OP of malonate, 3-OP of adipinate, 3-OP of maleate and 3-OP of a hemisuccinate derivatives influence on a process of the blood serum protein oxidative modification.
Materials and Methods. An investigation was conducted on the white breedless rats; an immobilization stress is selected as a factor, activating a process of the protein peroxidation. A method of the protein oxidative modification according to the carbonyl derivative level was used for assessment of the blood serum protein peroxidation process intensity. The investigating substances were directly infused before immobilization in 1 and 10% doses of an average lethal dose (LD50). The results were compared to the values, received in control groups — a group of intact animals and in a group of animals, undergoing immobilization without the substance infusion.
Results. The studied new derivatives of a 3-OP demonstrate a different inhibiting effect to a process of the protein oxidative modification, induced by immobilization stress. The given effect depends on a chemical structure and, apparently, on a biological role of the studied compound molecule components in the organism, and on a dose of infusing substances as well. The 3-OP adipinate in a dose of 1% of LD50, 3-OP oxalate in a dose of 1% of LD50, 3-OP hemisuccinate in a dose of 10% of LD50, 3-OP malonate in a dose of 10% of LD50 to a lesser extent possess of the antioxidant activity relating to a process of the protein peroxidation. 3-OP maleate has demonstrated no antioxidant effect.
