Chronic Inflammation and Fibrosis as Risk Factors of the Prostatic Intraepithelial Neoplasia (PIN) and Prostate Cancer
The aim of the investigation is to detect the PIN dissemination in patients with adenoma and prostate cancer (PC) and to prove a neoplasia and prostate cancer connection with chronic prostatitis and tissue fibrosis.
Materials and Methods. A retrospective analysis of case histories of 2316 males operated on benign hyperplasia of the prostate (BHP) and PC has been made in the urologic hospital.
Results. PIN in cancer has been found to exceed 2.3 times its revealing in a BHP. The 1st stage PIN appears to be more often associated with a BHP. The precancer alterations of the prostate epithelium are likely to be connected with chronic prostatitis and/or fibrosis. A probability of the PIN2 revealing increases with an inflammation increase. As for the probability of the prostate cancer revealing it is higher with a fibrosis degree increase (p=0.05).
