The Role of the Midmolecular Peptides in the Blood Cell Aggregation in Acute Periods of a Burn Disease
The aim of the investigation is to study the effect of midmolecular peptide (MMP) concentration on platelet and erythrocyte aggregation in severe burned patients.
Materials and Methods. The investigation was carried out on 34 blood samples of healthy people and 30 blood samples of severe burned patients. There was determined the level of MMP, as well as that of creatinine, and urea. The “Amicon Ultra-4” microcentrifuge tubes were used to isolate MMP.
Results. The level increase of average mass molecules isolated from the blood plasma of patients in an acute period of a burn disease has been stated to cause a progressive increase of platelet aggregation of healthy donors. The erythrocyte aggregation increase in such conditions is observed only in very high MMP concentrations.
Creatinine and urea do not practically effect the ADP-induced platelet aggregation and the erythrocyte aggregation of healthy donors, and even decrease spontaneous thrombocyte aggregation in very high concentrations occur in an acute renal insufficiency.
Conclusion. One of the reasons of platelet aggregation decrease under the influence of chemosorption in a burn disease can be the decrease of the MMP concentration in response to chemosorption.
