The Feasibility of an Extended Lymphadenectomy in Gastric Cancer Treatment
The aim of the investigation is to evaluate the tolerance of patients with advanced gastric cancer to extended D2 lymphodissection and its effect on the postoperative period.
Materials and Methods. The background of the research is the clinical observation of 288 patients within the age of 33 to 77 with morphologically verified stomach cancer. The 1st group (n=141) underwent the surgical treatment with lymphodissection D1 or D1+7, and the 2nd group (n=147) — the surgical treatment with lymphodissection D2.
Conclusion. With relevant experience and appropriate accompanying therapy, extended lymphodissection is well tolerated and safe. Increase in time of surgical treatment, the amount of blood loss and lymphorrhea, a slight increase in the frequency of postoperative pancreatitis are not fatal and do not lead to an increase in severe complications, such as lack of anastomosis, intraabdominal abscess and peritonitis. D2 lymphodissection does not result in an increase of postoperative mortality. Such volumes of surgical treatment can be performed in a standard oncologic dispensary.
- Davydov M.I. Aktovaya lektsiya «Sovremennaya onkokhirurgiya» [Commencement lecture “Modern Oncosurgery”]. Moscow: Izdatel’skaya gruppa RONTs: 2008; 32 p.
- Davydov M.I., Aksel’ E.M. Vestn Ross Onkol Naucn Centra im NN Blohina RAMN — Herald of Russian Oncological Scientific Centre named after N.N. Blokhin of RAMS 2008; 19(2, Suppl. 1): 57–100.
- Kutukov V.V., Kruglova T.S., Chernukhin A.A. Onkokhirurgiya — Oncosurgery 2008; 1: 43.
- Utin K.G., Vazhenin A.V. Akademicheskiy zhurnal Zapadnoy Sibiri. Onkologiya — Academic Journal of Western Siberia. Oncology. 2006; 5: 21–23.
- Chissov V.I., Vashakmadze L.A., Butenko A.V. et al. Ross Onkol Z — Russian Oncological Journal 1999; 2: 6–9.
- Chissov V.I., Vashakmadze L.A., Butenko A.V., Pikin O.V., Lozhkin M.V. Ross Onkol Z — Russian Oncological Journal 2001; 3: 9–12.
- Stilidi I.S., Nered S.N. Prakticheskaya onkologiya — Practical Oncology 2009; 1(10): 20–27.
- Yankin A.V. Prakticheskaya onkologiya — Practical Oncology 2009; 1(10): 12–19.
- Adachi Y., Kitano S., Sugimachi S. Surgery for gastric cancer: 10-year experience worldwide. Gastric cancer 2001; 4(4): 166–174.
- de Mansoni G., Verlato G., Guglielmi A. et al. Prognostic significance of lymph node dissection in gastric cancer. Br J Surg 1996; 83(11): 1604–1607.
- Sano T., Sasako M., Yamamoto S. et al. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy. Japan Clinical Oncology Group study 9501. J Clin Oncol 2004; 22(14): 2767–2773.
- Sasako M., Sano T., Yamamoto S. et al. D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. N Engl J Med 2008; 359: 453–462.
- Sawai K., Takahashi T., Suzuki H. New trends in surgery for gastric cancer. Jap J Surg Oncol 1994; 56: 221–226.
- Yokota T., Ishiyama S., Saito T. et al. Treatment strategy of limited surgery in the treatment guidelines for gastric cancer in Japan. The Lancet Oncology 2003; 4: 7.
- Davydov M.I., Ter-Ovanesov M.D. Sovremennaya onkologiya — Modern Oncology 2000; 2: 3–5.
- Davydov M.I., Ter-Ovanesov M.D., Abdikhakimov A.N. et al. Prakticheskaya onkologiya — Practical Oncology 2001; 3(7): 18–24.
- Japanese Classification of Gastric Cancer. 2nd English Edition. JGCA. Gastric Cancer 1998; 1(1): 10–24.
- Davydov M.I., Ter-Ovanesov M.D., Abdikhakimov A.N., Marchuk V.A. Prakticheskaya onkologiya — Practical Oncology 2001; 3(7): 9–24
- Vitebskiy Ya.D. Klapannye anastomozy v khirurgii pishchevaritel’nogo trakta [Valvular anastomoses in gastrointestinal surgery]. Moscow: Meditsina; 1998; 112 p.
- Japanese Research Society for Gastric Cancer. The general rules for the gastric cancer study in surgery and pathology. Japanese J Surg 1981; 11(2): 127–139.