Ximedon Administration in Complex Treatment of Chemical Burns of Esophagus and Stomach in Experiment
The aim of the investigation was to study in experiment the morphological changes in rat esophageal and gastric tissues after chemical burn using a regeneration enhancing agent (Ximedon) against the background of medical treatment.
Materials and Methods. Esophageal and gastric chemical burns were modeled on Wistar white rats (n=70) by 30% acetic acid. The survivors were divided into three groups: a control group (without therapy), a standard treatment group (the rats were administered cefotaxime and prednisolone intraperitoneally) and an experimental group (cefotaxime, prednisolone, Ximedon intraperitoneally). The results were assessed morphologically and morphometrically on day 13, 19 and 40.
Conclusion. Esophageal and gastric mucosa thickness after chemical burn does not recover under any treatment. Antibiotics and corticosteroids taken after burn inhibit inflammation in tissues, but do not prevent scar tissue development in muscularis mucosae. A long term (6 weeks) of Ximedon therapy along with standard therapy results in complete recovery of esophageal and gastric mucous structure and significantly suppresses a scarring process in muscular elements.
- George D. Ferry, Douglas S. Fishman. Caustic esophageal injury in children. 2013.www.uptodate.com/contents/caustic-esophageal-injury-in-children.
- Sakineh Fallahi, Seyed M.V. Hosseini, Soghra Fallahi, Morteza Salimi, Ali Akbar Hesam, Seydeh Hamideh Hoseini. Extent of injury of gastrointestinal tract due to accidental ingestion of chemicals among children at Bandar Abbass Children Hospital 2009–2011. Life Science Journal 2012; 9(4): 2054–2058.
- Volkov S.V., Ermolov A.S., Luzhnikov E.A. Khimicheskie ozhogi pishchevoda i zheludka (endoskopicheskaya diagnostika i lazeroterapiya) [Chemical burns of esophagus and stomach (endoscopic diagnosis and laser therapy)]. Moscow: Izdatel’skiy dom “Medpraktika-M”; 2005; 120 p.
- Rukevich S.G., Parshikov V.V., Batanov G.B., Karpova I.Yu. Primenenie sovremennoy klassifikatsii mnogokomponentnykh prizhigayushchikh veshchestv pri khimicheskikh ozhogakh pishchevoda i zheludka u detey. V kn.: Sbornik nauchnykh rabot konferentsii, posvyashchennoy 100-letiyu so dnya rozhdeniya professora A.A. Dikovoy [Application of modern classification of multicomponent cauterants in chemical burns of esophagus and stomach in children. In: Collection of scientific papers of the conference devoted to the 100th anniversary of the birth of Prof. A.A. Dikova]. Nizhny Novgorod; 2013.
- Corrosive esophageal injury. Professional health care portal “Health writing”. 2007.http://www.health-writings.com/corrosive-esophageal-injury/.
- Razumovskiy A.Yu., Obydennova R.V., Kulikova N.V., Alkhasov A.B., Rachkov V.E., Mitupov Z.B., Masenkov Yu.I. Evolyutsiya vzglyadov na khirurgicheskoe lechenie detey s khimicheskimi ozhogami pishchevoda [The evolution of surgical treatment for children with chemical burns of the esophagus]. Rossiyskiy vestnik detskoy khirurgii, anesteziologii i reanimatologii — Russian Vestnik of Pediatric Surgery, Anesthesiology and Resuscitation 2011; 1: 51–59.
- Alekseenko S.I., Bairov V.G., Tsurikova G.P., et al. Khimicheskie ozhogi pishchevoda u detey. V kn.: Sovremennye tekhnologii diagnostiki i lecheniya detey i podrostkov. Vypusk 2 [Chemical burns of esophagus. In: Modern technologies in diagnosis and treatment of children and adolescents]. Issue 2. Saint Petersburg; 2005; р. 25–30.
- Makarova O.L., Korolev M.P., Fedotov L.E. Taktika lecheniya bol’nykh s sochetannymi rubtsovymi strikturami pishchevoda i zheludka posle khimicheskikh ozhogov [Management of patients with concomitant esophageal and gastric corrosive strictures after chemical burns]. Ukrainskiy zhurnal maloinvazivnoy i endoskopicheskoy khirurgii — Ukrainian Journal of Minimally Invasive and Endoscopic Surgery 2003; 7(3): 39–40.
- Izmaylov S.G., Izmaylov M.Yu., Aver’yanov M.Yu., Reznik V.S. Ksimedon v meditsinskoy praktike [Ximedon in medical practice]. Nizhny Novgorod: Izdatel’stvo Nizhegorodskoy gos. med. akademii; 2001; 188 p.
