The Study of Complementarity of Iron Preparations with Antioxidants in an Experiment
The aim of the investigation is to study the effect of combined administration of iron preparations on lipid peroxidation indexes in tissues of various organs of experimental animals.
Materials and Methods. The experiment has been carried out on 130 non-pedigree male rats. As a part of the study there have been determined the indexes of induced biochemiluminescence and the content of malonic dialdehyde in tissues of intestine, liver, spleen and brain of experimental animals against the background of combined administration of iron preparations: ferric sulfate+serine (Aktiferrin) or ferric (III) hydroxide polymaltosate (Maltofer) — with antioxidants — ethylmethylhydroxypyridine succinate (Mexidol) or vitamin Е (Tocoppherol acetate).
Results. In combined administration of preparations of Aktiferrin+Mexidol, as well as Maltofer+Tocopherol acetate in tissues of all the organs studied, the balance between pro- and antioxidant systems is not upset and the mechanisms of antioxidant protection develop rather effectively. When preparations of Aktiferrin+Tocopherol acetate are administered in combination in such organs as intestine, liver and spleen, the balance between pro- and antioxidant systems is kept. In brain, within the period of investigation there is observed an intensifying effect on lipid peroxidation process only, with antioxidant system activity being weakened. In combined administration of preparations of Maltofer+Mexidol, the balance between pro- and antioxidant systems in liver tissues is not disordered. In the tissues of spleen and brain the balance between the systems mentioned is unstable. In the intestine in 5 days the preparations of Maltofer+Mexidol show pro-oxidant activity while the compensatory mechanisms of antioxidant activity within the studied period do not develop.
Conclusion. The most effective among the combinations of iron preparations with antioxidants analyzed are the following: Aktiferrin+Mexidol, as well as Maltofer+Tocopherol acetate. In combined administration of iron preparations with antioxidants, their highest complementarity should be taken into consideration.
