The Characteristics and Prognostic Significance of Sympathoadrenal Activity in Patients with Myocardial Infarction and Diabetes Mellitus Type 2
The aim of the investigation is to study the characteristics and prognostic significance of beta-adrenoreception of erythrocytes cell membranes (β-ARM) in patients with myocardial infarction (MI) with and without diabetes mellitus type 2 (DM2).
Materials and Methods. There was carried out complex clinicolaboratory examination of 27 patients with MI and DM2 and 21 patients with MI and without DM2 with β-ARM quantitative assessment.
Results. Beta-ARM index in patients with MI and DM2 was stated to be lower. It gave evidence of an increased receptor sensibility to endogenic catecholamines. β-ARM index decrease in DM2 was associated with a longer diabetic anamnesis, diabetic nephropathy, as well as the more severe MI in the form of the more frequent arrhythmias and the worst recovery potential of systolic function of the left ventricular myocardium. Decreased β-ARM indexes in patients without DM2 was also associated with the more severe MI as IV degree of MI, recurrences of early postinfarction angina pectoris and marked myocardial dysfunction.
