Experimental Justification of Enteral Lavage by Osmotically Active Solution in Acute Intestinal Obstruction Complicated by Intraabdominal Hypertension
The aim of the study is to determine the influence of intra-enteric pressure level on the mechanism causing decompensation of microcirculation defects in the wall of a small intestine and to assess the effectiveness of enteral lavage by hydroxyethyl amylum in case of an increased intra-enteric pressure in acute intestinal obstruction.
Materials and Methods. The experiment was carried out on 54 laboratory animals. In I series of the experiment (36 non-pedigree dogs) the processes of microcirculation in the wall of a small intestine depending on the increase level of intra-enteric pressure (5, 15, 25, 35 mm Hg) were studied. In the II series (18 rats) there was examined the effect of 10%-hydroxyethyl amylum solution on an inflammatory process in small intestine tissues when a critical level of intra-enteric pressure was adjusted.
Results. Under intra-enteric pressure in a small intestine of 15 mm Hg and more, decompensation disorders of splanchic microcirculation processes start. Under an adjusted critical level of intra-abdominal pressure, enteral lavage by 10%-hydroxyethyl amylum solution decreases the intensity of an inflammatory reaction in tissues of an intestinal wall in acute enteric obstruction.
