Antioxidant Activity of Pyrimidine Derivatives in Local Treatment of Septic Wounds of Soft Tissues (in an Experiment)
The aim of the study is to assess antioxidant activity of Xymedon in ointments in reparative process of septic wounds of soft tissues in the experiment on dogs.
Materials and Methods. To treat septic wounds, in I phase of wound process in the control group of animals Laevomecolum ointment was used, in the main group — Levoxycol, containing Laevomycetin — 0.75 g, Xymedon — 4 g, polyethylene oxides with molecular weight 1500 (ПЭО-1500) — 19.05 g, ПЭО-400 — 76.2 g. The effectiveness of treatment was assessed based on subjective (visual test of wound condition) and objective (microbiological, cytological investigations, biochemical test, planimetry) criteria. To assess oxidative process in paravulnar tissues, there were determined the activity of the enzymes of catalase and superoxide dismutase, lipid peroxidation activity (diene, triene conjugates and the number of olefinic links).
Results. Oxidation-reduction processes in paravulnar tissues were characterized by maximum values of lipid peroxidation before the treatment, at the height of inflammation. In the course of treatment there was tendency for gradual results normalization and the return to their initial level, however, in the main group treated by Levoxycol the tendency was more expressed.
Improved repair characteristics of ointments based on Xymedon can be explained mainly by the increase of antioxidant activity of superoxide dismutase and catalase that can be due to Xymedon as an activator of enzymes and endogenic antioxidant resulting from the process of it biotransformation.
