Diagnostic Significance of Cytokine Regulation Indexes in Prediction of Antivirus Therapy Effectiveness in Chronic Mixed Hepatitis B+C
The purpose of the work is to study the content of IL-1β, IL-2, IL-4, IL-6, TNF-α in patients with chronic mixed hepatitis В+С, as well as their dynamics in the process of antivirus therapy (AVT) to reveal possible predictors of stable virologic response concerning chronic hepatitis C and virologic response in regard to chronic hepatitis B.
Materials and Methods. Cytokine status has been studied in 53 patients with chronic mixed hepatitis В+С, and there has been analyzed the dynamics of interleukin levels (IL-1β, IL-2, IL-4, IL-6), TNF-α в in AVT process.
Conclusion. The cytokine profile variation in patients with chronic mixed hepatitis В+С confirmed the presence of Th2 type immune response (regardless HBV/HCV replicative activity) that was the basis of chronic process. The use of AVT contributed to the IL-2 production increase taking an active part in Th1 type immune response. Significant increase of IL-2 level by the end of the first month of antivirus therapy can be an additional criterion of predicting a stable VR in HCV RNA-positive patients and virologic response in HBV DNA-positive patients. The increase of TNF-α content is half as much on the 4—6th week with further decrease up to initial level or lower by the 8—10th week of treatment is to be considered an additional prognostic criterion of therapy effectiveness when carrying out AVT in the case of chronic hepatitis B with high replicative activity.
