The Significance of Soluble Differentiation Antigens in the Prognosis of Herpes Zoster and the Effectiveness of Antiviral and Immunocorrigent Therapy

The aim of the investigation is to assess the content of soluble forms of differentiation antigens in patients with herpes zoster depending on sex, age, severity of the disease, associated diseases, laboratory findings, in patients with postherpetic neuralgia in the process of follow-up, and show their significance in the prognosis of the course of the disease and the efficiency of antiviral and immunocorrigent therapy.

Materials and Methods. Immune reaction has been studied in 62 patients with herpes zoster, aged 35–85 years. The content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50, sHLA-I, sCD54) has been studied by the method of enzyme immunoassay using monoclonal antibodies ICO 20 and polyclonal antibodies to antigens of mononuclear cells of human peripheral blood.

Results. The factors contributing to non-complicated course of herpetic infection have been stated to be the age under 60, moderate severity of the disease, rash localized on the trunk, the absence of associated diseases, increase of sHLA-I — 1.5–2 times as much compared to control values. Cofactors of postherpetic neuralgia was old age (over 60), severe course of the disease, rash on the head, the presence of associated diseases, increased level of blood urea, decrease of sCD95 and sCD54 — 1.5–2 times as much compared to control values. If there are the abovementioned factors, antiviral and immunocorrigent therapy is required the sooner the better.

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Sobchak D.М., Svintsova Т.А., Korochkina О.V., Kravchenko G.А., Novikov V.V. The Significance of Soluble Differentiation Antigens in the Prognosis of Herpes Zoster and the Effectiveness of Antiviral and Immunocorrigent Therapy. Sovremennye tehnologii v medicine 2011; (4): 70