Actual Radiodiagnosis Technologies of Hepatic Cancer
The aim of the investigation was to study the possibilities of computer tomography with intravenous contrast and multiphase scanning and magnetic resonance tomography using hepatospecific contrast substance — gadoxetic acid — in hepatic cancer diagnostics.
Materials and Methods. Within the period of 2008–2011 on the basis of Kirov Regional War Veterans Hospital and Kirov Regional Clinical Hospital there was carried out the complete clinical and radiological examination of 60 patients with hepatic cancer. Primary liver tumors were diagnosed in 23 patients. Metastatic tumors were revealed in 37 patients.
Abdominal multispiral computed tomography (CT) was performed in 45 patients (75%). 31 patients (52%) underwent magnetic resonance tomography (MRT) of abdominal and retroperitoneal organs.
Conclusion. Actual CT and MRT technologies with intravenous contrast and multiphase scanning are high-quality and informative in topical and differential diagnosis of liver tumors. The application of hepatospecific contrast substance — gadoxetic acid — expands MRT opportunities in detection and recognition of small (less than 1 cm) liver metastases.
Differential radiodiagnosis of focal liver lesions (using CT and MRT) should be based on multicentre study of morphological structure, the character of lesion vascularity, and their dynamic and organ-specific (in MRT — in hepatocyte phase) contrast.
- Zhuravlev V.A. Aktual’nye, spornye i nereshennye voprosy khirurgii pecheni [Relevant, disputable and open issues of hepatic surgery]. Kirov; 2008; 277 p.
- Patyutko Yu.I. Khirurgicheskoe lechenie zlokachestvennykh opukholey pecheni [Operative therapy of hepatic cancer]. Moscow: Prakticheskaya meditsina; 2005; 312 p.
- Bosch F.X., Ribes J., Diaz M., Cleries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004; 127: S5–S16.
- Bosetti C., Levi F., Boffetta P., Lucchini F., Negri E., La Vecchia C. Trends in mortality from hepatocellular carcinoma in Europe, 1980–2004. Hepatology 2008; 48: 137–145.
- Karmazanovskiy G.G. Spiral’naya komp’yuternaya tomografiya: bolyusnoe kontrastnoe usilenie [Spiral computer tomography: bolus contrast enhancement]. Moscow: Vidar-M; 2005; 376 p.
- Bolog N., Andreisek G., Oancea I., Mangrau A. CT and MR imaging of hepatocellular carcinoma. J Gastrointestin Liver Dis 2011; 20(2): 181–189.
- Efremidis S.C., Hytiroglou P. The multistep process of hepatocarcinogenesis in cirrhosis with imaging correlation. European Radiology 2002; 2: 753–764.
- Bruix J., Sherman M. Management of hepatocellular carcinoma: an update. Alexandria (VA): American Association for the Study of Liver Diseases; 2010; 35 p.
- Karmazanovskiy G.G., Shimanovskiy N.L. Meditsinskaya vizualizatsiya — Medical Imaging 2007; 6: 135–143.
- Burns P.N., Wilson S.R. Focal liver masses: enhancement patterns on contrast-enhanced images — concordance of US scans with CT scans and MR images. Radiology 2007; 242(1): 162–174.
- Ichikawa T., Saito K., Yoshioka N., et al. Detection and characterization of focal liver lesions a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular carcinoma and chronic liver disease. Investigative Radiology 2010; 45(3): 1–9.
- Huppertz A., Yariada S., Kraus A., et al. Enhancement of focal liver lesions at gadoxetic acid-enhanced MR-imaging: correlation with histopatologic findings and spiral CT — initial observations. Radiology 2005; 234(2): 468–478.
- Luca A., Grazioli L., Caruso S., et al. A two-centre study for the comparison of Gd-EOB-STPA (Primovist)-enhanced MRI versus triple-phase MDCT for the detection of hepatocellular carcinoma in cirrhosis. European Radiology 2009; 19(Suppl 1): S162.
- Zech C.J., Grazioli L., Jonas E., et al. Health-economic evaluation of three imaging strategies in patients with suspected colorectal liver metastases: Gd-EOB-DTPA-enhanced MRI vs. extracellular contrast media-enhanced MRI and 3-phase MDCT in Germany, Italy and Sweden. European Radiology 2009; 19(Suppl 3): S753–S763.