Today: Dec 3, 2024
RU / EN
Last update: Oct 30, 2024
The Relationship of Spirographic Parameters and Bronchial Responsiveness with Asthma Control Level in Children (According to ACQ-5 and АСТ-С Data)

The Relationship of Spirographic Parameters and Bronchial Responsiveness with Asthma Control Level in Children (According to ACQ-5 and АСТ-С Data)

Eliseeva Т.I., Knyazeva Е.V., Geppe N.A., Balabolkin I.I.
Key words: bronchial asthma; spirographic parameters; bronchial responsiveness; ACQ-5; АСТ-С.
2013, volume 5, issue 2, page 47.

Full text

pdf
0
2228

The aim of the investigation was to assess the relationship of ACQ-5 and ACT-C indices and spirographic parameters in children with bronchial asthma (BA), reveal confidential intervals of these parameters typical for different levels of BA control. The BA levels were determined according to these questionnaires.

Materials and Methods. We examined 130 patients aged from 5 to 11 years with primarily atopic BA and different control level of the disease. In addition to routine examination, all children underwent the tests to determine BA control level using Asthma control questionnaire — 5 (ACQ-5) and Childhood Asthma control test (АСТ-С). Spirographic examination was performed using Master-Screen Pneumo (Jaeger, Germany). Bronchial hyperresponsiveness was studied in tests with physical load (veloergometer Kettler AX1). The test with bronchial spasmolytic was used in children with exacerbation of the disease.

Results. According to ACQ-5, 90 children had complete control of the disease symptoms (ACQ-5<0.75 scores), 17 children — partial control (0.751.5 scores). According to АСТ-С, in the same children, 95 children had controlled BA course (АСТ-С20 scores), 35 patients — lack of control (АСТ-С19). The correlation between ACQ-5 and АСТ-С was –0.62, when p<0.00001.

The control level assessment according to ACQ-5 showed the average values of forced expiratory volume in 1 s (FEV1) in patients with complete BA control to be 98.99±10.56%, with partial control — 91.53±10.94%, with no control — 72.56±7.17%, p<0.00001. The correlation between ACQ-5 and FEV1 was –0.7, when p<0.00001.
The control level estimated by ACT-C showed the average values of FEV1 in patients with the achieved BA control to be 95.78±12.38%, with the lack of control — 85.99±17.08%; p=0.0007. The correlation between ACT-C and FEV1 was 0.37, when p<0.00001.
We assessed the intensity of bronchial responsiveness estimated by the tests with physical load or with bronchial spasmolytics (taking into consideration initial clinical status and spirogram findings) in 40 patients. As BA control level decreased, there was found the bronchial responsiveness rising. The correlation between ACQ-5 and the intensity of bronchial responsiveness was 0.55, when p=0.0001, that exceeded the correlation relationship between ACT-C and this parameter (R=0.33; p=0.03).

Conclusion. When diagnosing BA control level, one should take into consideration that spirographic parameters, as well as the intensity of bronchial responsiveness in the conditions of modern pharmacotherapy, demonstrate closer correlation with ACQ-5 indices compared to АСТ-С.

  1. GINA (Global strategy for asthma management and prevention). Updated 2011. http: //www.ginasthma.org/uploads/users/files/GINA_Report_2011.pdf
  2. Volkov I.K., Geppe N.A., Kondyurina E.G., Korostovtsev D.S., et al. Natsional’naya programma “Bronkhial’naya astma u detey. Strategiya lecheniya i profilaktika” [National program “Bronchial asthma in children. Management strategy and prevention”]. Moscow: Original-maket; 2012; 184 p.
  3. Reddel H.K., Taylor D.R., Bateman E.D., et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations. standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009; 180(1): 59–99.
  4. Sazlidere H., Celikel S., Inönü H., Doruk S., et al. The relation between nitric oxide levels in exhaled breath condensate and asthma control questionnaires in asthma patients. Tuberk Toraks 2010; 58(1): 5–15.
  5. Lopes C., Fonseca J., Delgado L., Moreira A., Barros R., Moreira P., Castelo-Branco Mda G. Assessing asthma control: questionnaires and exhaled nitric oxide provide complementary information. Eur Respir J 2008; 32(5): 1419–20.
  6. Shirai T., Furuhashi K., Suda T., Chida K. Relationship of the asthma control test with pulmonary function and exhaled nitric oxide. Ann Allergy Asthma Immunol 2008; 101(6): 608–613.
  7. Waibel V., Ulmer H., Horak E. Assessing asthma control: symptom scores, GINA levels of asthma control, lung function, and exhaled nitric oxide. Pediatr Pulmonol 2012; 47(2): 113–118.
  8. Piacentini G.L., Peroni D.G., Bodini A., Bonafiglia E., et al. Childhood Asthma Control Test and airway inflammation evaluation in asthmatic children. Allergy 2009; 64(12): 1753–1757.
  9. Papakosta D., Latsios D., Manika K., Porpodis K. Asthma Control Test is correlated to FEV1 and nitric oxide in Greek asthmatic patients: influence of treatment. J Asthma 2011; 48(9): 901–906.
  10. Alvarez-Gutiérrez F.J., Medina-Gallardo J.F., Pérez-Navarro P., Martn-Villasclaras J.J., et al. Comparison of the Asthma Control Test (ACT) with lung function, levels of exhaled nitric oxide and control according to the Global Initiative for Asthma (GINA). Arch Bronconeumol 2010; 46(7): 370–377.
  11. Juniper E.F., Gruffydd-Jones K., Ward S., Svensson K. Asthma control questionnaire in children validation, measurement properties, interpretation. Eur Respir J 2010; 36: 1410–1416.
  12. Liu A.H., Zeiger R.S., Sorkness C., Mahr T., et al. Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol 2007; 119(4): 817–825.
  13. Shiryaeva I.S., Lukina O.F., Reutova B.C., et al. Funktsional’nye metody issledovaniya bronkhial’noy prokhodimosti u detey [Functional diagnostic techniques of bronchial patency in children]. Moscow: MZ SSSR; 1990.
  14. Silverman M., Anderson S.D., Andrea T. Standardization of exercise tests in asthmatic children. Arch Dis Child 1972; 47(256): 882–889.
Eliseeva Т.I., Knyazeva Е.V., Geppe N.A., Balabolkin I.I. The Relationship of Spirographic Parameters and Bronchial Responsiveness with Asthma Control Level in Children (According to ACQ-5 and АСТ-С Data). Sovremennye tehnologii v medicine 2013; 5(2): 47


Journal in Databases

pubmed_logo.jpg

web_of_science.jpg

scopus.jpg

crossref.jpg

ebsco.jpg

embase.jpg

ulrich.jpg

cyberleninka.jpg

e-library.jpg

lan.jpg

ajd.jpg

SCImago Journal & Country Rank