Exoskeleton as a New Means in Habilitation and Rehabilitation of Invalids (Review)

The problem of development and implementation of exoskeletons has been analyzed on the basis of the Russian and foreign literature. Military industry and rehabilitation medicine are shown to be currently the priority fields of exoskeleton application. It has been noted, that the majority of the existing exoskeletons cannot be widely used for the rehabilitation of the patients with limited functions of the upper and lower limbs because they are heavy, external power supply-dependent, and expensive. Two types of exoskeletons, active and passive, have been considered. The design of the passive exoskeleton is shown to be most acceptable for use. The analysis has revealed, that the main groups requiring exoskeletons, include patients suffering from paresis of the upper and lower limbs.

1. Ekzoskelet [Exoskeleton]. Vikipediya. URL: http://ru.wikipedia.org/?oldid=67717712 (accessed: 12.02.2015).
2. Ekzoskelet — voennoe i mirnoe primenenie [Exoskeleton — military and peaceful application]. Glavnyy mekhanik 2011; 11: 50–54.
3. Bednyak S.G., Eremina O.S. Robotizirovannye ekzoskelety HAL (pochuvstvuy sebya HAL’kom). V kn.: Sbornik nauchnykh trudov Sworld. Vyp. 2. T. 1 [Robotic exoskeletons HAL (feel yourself a HAL’er). In: Collection of scientific works Sworld. Issue 2. Vol. 1]. Odessa; 2014; p. 49–51.
4. HULC. Lockheed Martin. URL: http://www.lockheedmartin.com/us/products/hulc.html.
5. Binkiewicz-Glinska A., Sobierajska-Rek A., Bakula S., Wierzba J., Drewek K., Kowalski I.M., Zaborowska-Sapeta K. Arthrogryposis in infancy, multidisciplinary approach: case report. BMC Pediatr 2013; 13: 184, http://dx.doi.org/10.1186/1471-2431-13-184.
6. Technologies: iron soldiers. “Bratishka” zhurnal dlya spetsnaza 2011; 1: 37–41.
7. Raytheon XOS 2 exoskeleton, second-generation robotics suit, United States of America. URL: http://www.army-technology.com/projects/raytheon-xos-2-exoskeleton-us (дата обращения: 27.12.2014).
8. A human exoskeleton. Washington Post 2008 May 6. URL: http://www.washingtonpost.com/wp-dyn/content/article/2008/05/02/AR2008050203382.html.
9. Paraplegic support suits. TrendHunter. Published: Apr 4, 2008. URL: http://www.trendhunter.com/trends/helping-paraplegics-walk-rewalk-exoskeleton.
10. Rewalk’ bionic legs get FDA approval. News.com.au. Published: 17 Jan, 2011. URL: http://www.news.com.au/technology/rewalk-bionic-legs-get-fda-approval/story-e6frfro0-1225989332272.
11. Rosen M. Mind to motion: brain-computer interfaces promise new freedom for the paralyzed and immobile. Science News 2013; 184(10): 22–24, http://dx.doi.org/10.1002/scin.5591841017.
12. Moreno J., Turowska E., Pons J.L. Wearable lower limb and full-body robots. In: Wearable robots: biomechatronic exoskeletons. Edited by Pons J.L. Wiley; 2008; p. 283–321.
13. eLEGS™. Berkeley robotics and human engineering laboratory. URL: http://bleex.me.berkeley.edu/research/exoskeleton/elegs%E2%84%A2.
14. Kazerooni H. Human augmentation and exoskeleton systems in Berkeley. Int J Human Robot 2007; 4(3): 575–605, http://dx.doi.org/10.1142/S0219843607001187.
15. Avril T. Instant strength from the Titan Arm. The Philadelphia Inquirer 2013 Jun. URL: http://titanarm.com.
16. Zolfagharifard E. The wearable robot that turns anyone into a SUPERHERO: bionic arm lets users lift an extra 40lb effortlessly. Mail Online Published: 10 Dec, 2013. URL: http://www.dailymail.co.uk/sciencetech/article-2521245/Titan-Arm-bionic-exoskeleton-lets-users-lift-extra-40lb-effortlessly.html.
17. Passive exoskeleton “K-2”. Transportnye shagayushchie sistemy. URL: http://twsystem.ru/ru/node/6.
18. A medical exoskeleton for rehabilitation. ExoAtlet. URL: http://www.exoatlet.ru.
19. Russian scientists presented the first working model of an exoskeleton for assault units and emergencies rescuers. Nano News Net. Published: 22 Aug, 2013. URL: http://www.nanonewsnet.ru/news/2013/rossiiskie-uchenye-predstavili-pervyi-deistvuyushchii-obrazets-ekzoskeleta-dlya-shturmovyk.
20. Vukobratovic M.K. When were active exoskeletons actually born? Int J Human Robot 2007; 3(4): 459–486, http://dx.doi.org/10.1142/S0219843607001163.
21. On the outer suspension. Nauka i zhizn’ 2013; 10: 39.
22. Avedikov G.E., Zhmakin S.I., Ibragimov V.S., Ivanov A.V., Kobrin A.I., Komarov P.A., et al. Ekzoskelet: konstruktsiya, upravlenie. V kn.: XII Vserossiyskoe soveshchanie po problemam upravleniya VSPU-2014 [Exoskeleton: design and control. In: The XII All-Russian conference on the problems of control “VSPU-2014”]. Moscow; 2014; p. 84–90.
23. Park Y.-L., Chen B., Pérez-Arancibia N.O., Young D., Stirling L., Wood R.J., et al. Design and control of a bio-inspired soft wearable robotic device for ankle, foot rehabilitation. Bioinspir Biomim 2014; 9(1): 016007, http://dx.doi.org/10.1088/1748-3182/9/1/016007.
24. Farris D.J., Hicks J.L., Delp S.L., Sawicki G.S. Musculoskeletal modelling deconstructs the paradoxical effects of elastic ankle exoskeletons on plantar-flexor mechanics and energetics during hopping. J Exp Biol 2014; 217(22): 4018–4028, http://dx.doi.org/10.1242/jeb.107656.
25. To C.S., Kobetic R., Bulea T.C., Audu M.L., Schnellenberger J.R., Pinault G., et al. Sensor-based hip control with hybrid neuroprosthesis for walking in paraplegia. J Rehabil Res Dev 2014; 51(2): 229–244, http://dx.doi.org/10.1682/JRRD.2012.10.0190.
26. Mooney L.M., Rouse E.J., Herr H.M. Autonomous exoskeleton reduces metabolic cost of human walking. J Neuroeng Rehabil 2014; 11(1): 151, http://dx.doi.org/10.1186/1743-0003-11-151.
27. Nilsson A., Vreede K.S., Häglund V., Kawamoto H., Sankai Y., Borg J. Gait training early after stroke with a new exoskeleton — the hybrid assistive limb: a study of safety and feasibility. J Neuroeng Rehabil 2014; 11(1): 92, http://dx.doi.org/10.1186/1743-0003-11-92.
28. Murray S.A., Ha K.H., Hartigan C., Goldfarb M. Assistive control approach for a lower-limb exoskeleton to facilitate recovery of walking following stroke. IEEE Trans Neural Syst Rehabil Eng 2014; 99: 1, http://dx.doi.org/10.1109/tnsre.2014.2346193.
29. Del-Ama A.J., Gil-Agudo A., Pons J.L., Moreno J.C. Hybrid FES-robot cooperative control of ambulatory gait rehabilitation exoskeleton. J Neuroeng Rehabil 2014; 11: 27, http://dx.doi.org/10.1186/1743-0003-11-27.
30. Cruciger O., Schildhauer T.A., Meindl R.C., Tegenthoff M., Schwenkreis P., Citak M., Aach M. Impact of locomotion training with a neurologic controlled hybrid assistive limb (HAL) exoskeleton on neuropathic pain and health related quality of life (HRQoL) in chronic SCI. Disabil Rehabil Assist Technol 2014; 10: 1–6, http://dx.doi.org/10.3109/17483107.2014.981875.
31. Fleerkotte B.M., Koopman B., Buurke J.H., van Asseldonk E.H., van der Kooij H., Rietman J.S. The effect of impedance-controlled robotic gait training on walking ability and quality in individuals with chronic incomplete spinal cord injury: an explorative study. J Neuroeng Rehabil 2014; 11: 26, http://dx.doi.org/10.1186/1743-0003-11-26.
32. van Dijk W., van der Kooij H., van der Kooij H. Optimization of human walking for exoskeletal support. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650394.
33. Rosen J., Perry J.C. Upper limb powered exoskeleton. Int J Human Robot 2007; 4(3): 529–548, http://dx.doi.org/10.1142/s021984360700114x.
34. Wang S., Wang L., Meijneke C., van Asseldonk E., Hoellinger T., Cheron G., Ivanenko Y., La Scaleia V., Sylos-Labini F., Molinari M., Tamburella F., Pisotta I., Thorsteinsson F., Ilzkovitz M., Gancent J., Nevatia Y., Hauffe R., Zanow F., van der Kooij. Design and control of the MINDWALKER exoskeleton. IEEE Trans Neural Syst Rehabil Eng 2015; 232(2): 277–286, http://dx.doi.org/10.1109/tnsre.2014.2365697.
35. Knaepen K., Beyl P., Duerinck S., Hagman F., Lefeber D., Meeusen R. Human-robot interaction: kinematics and muscle activity inside a powered compliant knee exoskeleton. IEEE Trans Neural Syst Rehabil Eng 2014; 22(6): 1128–1137, http://dx.doi.org/10.1109/TNSRE.2014.2324153.
36. Shamaei K., Cenciarini M., Adams A.A., Gregorczyk K.N., Schiffman J.M., Dollar A.M. Design and evaluation of a quasi-passive knee exoskeleton for investigation of motor adaptation in lower extremity joints. IEEE Trans Biomed Eng 2014; 61(6): 1809–1821, http://dx.doi.org/10.1109/TBME.2014.2307698.
37. Cempini M., Marzegan A., Rabuffetti M., Cortese M., Vitiello N., Ferrarin M. Analysis of relative displacement between the HX wearable robotic exoskeleton and the user’s hand. J Neuroeng Rehabil 2014; 11: 147, http://dx.doi.org/10.1186/1743-0003-11-147.
38. Nasiłowski K., Awrejcewicz J., Lewandowski D. Kinematic analysis of the finger exoskeleton using MATLAB/Simulink. Аcta Bioeng Biomech 2014; 16(3): 129–134.
39. Talaty M., Esquenazi A., Briceno J.E. Differentiating ability in users of the ReWalk(TM) powered exoskeleton: an analysis of walking kinematics. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650469.
40. Ryder M.C., Sup F. Leveraging gait dynamics to improve efficiency and performance of powered hip exoskeletons. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650440.
41. Elliott G., Sawicki G.S., Marecki A., Herr H. The biomechanics and energetics of human running using an elastic knee exoskeleton. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650418.
42. Esmaeili M., Jarrasse N., Dailey W., Burdet E., Campolo D. Hyperstaticity for ergonomie design of a wrist exoskeleton. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650417.
43. Cempini M., De Rossi S.M., Lenzi T., Cortese M., Giovacchini F., Vitiello N., Carrozza M.C. Kinematics and design of a portable and wearable exoskeleton for hand rehabilitation. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650414.
44. Ates S., Lobo-Prat J., Lammertse P., van der Kooij H., Stienen A.H. SCRIPT passive orthosis: design and technical evaluation of the wrist and hand orthosis for rehabilitation training at home. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650401.
45. Wu T.M., Chen D.Z. Biomechanical study of upper-limb exoskeleton for resistance training with three-dimensional motion analysis system. J Rehabil Res Dev 2014; 51(1): 111–126, http://dx.doi.org/10.1682/JRRD.2012.12.0227.
46. Hassan M., Kadone H., Suzuki K., Sankai Y. Wearable gait measurement system with an instrumented cane for exoskeleton control. Sensors 2014; 14(1): 1705–1722, http://dx.doi.org/10.3390/s140101705.
47. Pehlivan A.U., Rose C., O’Malley M.K. System characterization of RiceWrist-S: a forearm-wrist exoskeleton for upper extremity rehabilitation. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650462.
48. Klauer C., Schauer T., Reichenfelser W., Karner J., Zwicker S., Gandolla M., Ambrosini E., Ferrante S., Hack M., Jedlitschka A., Duschau-Wicke A., Gfühler M., Pedrocchi A. Feedback control of arm movements using neuro-muscular electrical stimulation (NMES) combined with a lockable, passive exoskeleton for gravity compensation. Front Neurosci 2014; 8, http://dx.doi.org/10.3389/fnins.2014.00262.
49. Vereykin A.A., Koval’chuk A.K., Kulakov D.B., Semenov S.E., Karginov L.A., Kulakov B.B., Yarots V.V. Sintez kinematicheskoy skhemy ispolnitel’nogo mekhanizma ekzoskeleta. V kn.: III Mezhdunarodnaya nauchno-prakticheskaya konferentsiya “Aktual’nye voprosy nauki” [Synthesis of the kinematic scheme of the exoskeleton operating mechanism. In: The III International scientific-practical conference “Actual problems of science”]. Moscow; 2014; p. 68–76.
50. Vorob’ev A.A., Kamaev V.A., Petrukhin A.V., Egin E.I., Poroyskiy S.V., Barinov A.S., Egin M.E., Kraynev A.V., Andryushchenko F.A. Feasibility of using computer analysis of virtual topographo-anatomic media in medicine. Izvestiya Volgogradskogo gosudarstvennogo tekhnicheskogo universiteta 2006; 4: 34–35.
51. Vorob’ev A.A., Kamaev V.A., Petrukhin A.V., Egin E.I., Poroyskiy S.V., Barinov A.S., Egin M.E., Kraynev A.V., Andryushchenko F.A. Intellectualization of diagnosis procedures using computed X-ray and magnetic resonance imaging on the basis of synthesis and analysis of virtual topographo-anatomic media. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta 2005; 3: 3–6.
52. Petrukhin A.V., Zolotarev A.V. Method for automation of the initial stages of biochemical system design. Informatsionnye tekhnologii 2010; 5: 73–76.
53. Borovin G.K., Kostyuk A.V., Seet G. Computer simulation of the hydraulic control system for exoskeleton. Preprint, Inst. Appl. Math., the Russian Academy of Science; 2004.
54. Borisov A.V. Automation of rod exoskeleton design. Mekhatronika, avtomatizatsiya, upravlenie 2014; 10: 29–33.
55. Borovin G.K., Kostyuk A.V., Sit D. Mathematical simulation of the hydraulic system for exoskeleton control. Preprinty IPM im. M.V. Keldysha; 2004.
56. Cortés C., Ardanza A., Molina-Rueda F., Cuesta-Gуmez A., Unzueta L., Epelde G., Ruiz O.E., De Mauro A., Florez J. Upper limb posture estimation in robotic and virtual reality-based rehabilitation. Biomed Res Int 2014, http://dx.doi.org/10.1155/2014/821908.
57. Agarwal P., Kuo P.H., Neptune R.R., Deshpande A.D. A novel framework for virtual prototyping of rehabilitation exoskeletons. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650382.
58. Wang S., Meijneke C., van der Kooij H. Modeling, design, and optimization of Mindwalker series elastic joint. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650381.
59. Smith R.L., Lobo-Prat J., van der Kooij H., Stienen A.H.A. Design of a perfect balance system for active upper-extremity exoskeletons. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650376.
60. Meuleman J., van Asseldonk E.H.F., van der Kooij H. Novel actuation design of a gait trainer with shadow leg approach. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650369.
61. Chen Y., Li G., Zhu Y., Zhao J., Cai H. Design of a 6-DOF upper limb rehabilitation exoskeleton with parallel actuated joints. Biomed Mater Eng 2014, 24(6): 2527–2535, http://dx.doi.org/10.3233/BME-141067.
62. Sylos-Labini F., La Scaleia V., d’Avella A., Pisotta I., Tamburella F., Scivoletto G., Molinari M., Wang S., Wang L., van Asseldonk E., van der Kooij H., Hoellinger T., Cheron G., Thorsteinsson F., Ilzkovitz M., Gancet J., Hauffe R., Zanov F., Lacquaniti F., Ivanenko Y.P. EMG patterns during assisted walking in the exoskeleton. Front Hum Neurosci 2014; 8: 423, http://dx.doi.org/10.3389/fnhum.2014.00423.
63. Borisoff J.F., Mattie J., Rafer V. Concept proposal for a detachable exoskeleton-wheelchair to improve mobility and health. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650396.
64. Yu H., Huang S., Thakor N.V., Chen G., Toh S.L., Sta Cruz M., Ghorbel Y., Zhu C. A novel compact compliant actuator design for rehabilitation robots. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650478.
65. Masia L., Cappello L., Morasso P., Lachenal X., Pirrera A., Weaver P., Mattioni F. CARAPACE: a novel composite advanced robotic actuator powering assistivecompliant exoskeleton: preliminary design. IEEE Int Conf Rehabil Robot 2013; 6650511, http://dx.doi.org/10.1109/ICORR.2013.6650511.
66. Galinski D., Sapin J., Dehez B. Optimal design of an alignment-free two-DOF rehabilitation robot for the shoulder complex. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650502.
67. Rahman T., Sample W., Jayakumar S., King M.M., Wee J.Y., Seliktar R., Alexander M., Scavina M., Clark A. Passive exoskeletons for assisting limb movement. J Rehabil Res Dev 2006; 43(5): 583–590, http://dx.doi.org/10.1682/JRRD.2005.04.0070.
68. Rahman T., Sample W., Seliktar R., Alexander M., Scavina M. A body-powered functional upper limb orthosis. J Rehabil Res Dev 2000; 37(6): 675–680, http://dx.doi.org/10.1109/tnsre.2007.897026.
69. Gradetskiy V.G. Modelirovanie dvizheniy cheloveka dlya promyshlennykh primeneniy [Simulation of human movements for industrial applications]. Moscow; 2008.
70. Gradetskiy V.G., Ermolov I.L., Knyaz’kov M.M., Semenov E.A., Sukhanov A.N. Application of unloading elements in robot-exoskeleton design. Mekhatronika, avtomatizatsiya, upravlenie 2012; 11: 20–23.
71. Gradetskiy V.G., Ermolov I.L., Knyaz’kov M.M., Semenov E.A., Sukhanov A.N. Kinematic model of the human arm exoskeleton and positioning error determination. Mekhatronika, avtomatizatsiya, upravlenie 2014; 5: 37–41.
72. Vorob’ev A.A., Petrukhin A.V., Zasypkina O.A., Krivonozhkina P.V. Clinical and anatomic requirements to the active and passive upper limb exoskeletons. Volgogradskiy nauchno-meditsinskiy zhurnal 2014; 1: 56–61.
73. Vorob’ev A.A., Petrukhin A.V., Zasypkina O.A., Krivonozhkina P.V. The basic clinical and anatomic criteria for upper limb exoskeleton development. Zhurnal anatomii i gistopatologii 2014; 1: 20–26.
74. Vorob’ev A.A., Petrukhin A.V., Zasypkina O.A., Krivonozhkina P.V. Clinical and anatomic justification of the requirements to the development of the upper limb exoskeletons. Orenburgskiy meditsinskiy vestnik 2014; 3(II): 14–18.
75. Minzdravsotsrazvitiya Rossii, Departament trudovykh otnosheniy i gosudarstvennoy grazhdanskoy sluzhby. Kontseptsiya Programmy deystviy po uluchsheniyu usloviy i okhrany truda, vklyuchaya provedenie attestatsii rabochikh mest po usloviyam truda [Ministry of Health and Social Development of the Russian Federation, Department of Labor Relations and State Civil Service. A concept of the Program of Actions for improvement of working conditions and labor protection, including assessment of workplaces with respect to working conditions]. Moscow; 2008.
76. Cortés C., Ardanza A., Molina-Rueda F., Cuesta-Gómez A., Unzueta L., Epelde G., Ruiz O.E., De Mauro A., Florez J. Upper limb posture estimation in robotic and virtual reality-based rehabilitation. Biomed Res Int 2014, http://dx.doi.org/10.1155/2014/821908.
77. Mao Y., Jin X., Dutta G.G., Scholz J.P., Agrawal S.K. Human movement training with a cable driven ARm EXoskeleton (CAREX). IEEE Trans Neural Syst Rehabil Eng 2015; 23(1): 84–92, http://dx.doi.org/10.1109/TNSRE.2014.2329018.
78. Mao Y., Jin X., Agrawal S.K. Real-time estimation of glenohumeral joint rotation center with cable-driven arm exoskeleton (CAREX)-A cable-based arm exoskeleton. J Mech Robot 2014; 6(1): 014502, http://dx.doi.org/10.1115/1.4025926.
79. Chang W.H., Kim Y.H. Robot-assisted therapy in stroke rehabilitation. J Stroke 2013; 15(3): 174–181, http://dx.doi.org/10.5853/jos.2013.15.3.174.
80. Klamroth-Marganska V., Blanco J., Campen K., Curt A., Dietz V., Ettlin T., Felder M., Fellinghauer B., Guidali M., Kollmar A., Luft A., Nef T., Schuster-Amft C., Stahel W., Riener R. Three-dimensional, task-specific robot therapy of the arm after stroke: a multicentre, parallel-group randomised trial. Lancet Neurol 2014; 13(2): 159–166, http://dx.doi.org/10.1016/S1474-4422(13)70305-3.
81. Grimaldi G., Manto M. Functional impacts of exoskeleton-based rehabilitation in chronic stroke: multi-joint versus single-joint robotic training. J Neuroeng Rehabil 2013; 10: 113, http://dx.doi.org/10.1186/1743-0003-10-113.
82. Simkins M., Kim H., Abrams G., Byl N., Rosen J. Robotic unilateral and bilateral upper-limb movement training for stroke survivors afflicted by chronic hemiparesis. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650506.
83. Weiss P., Heyer L., Munte T.F., Heldmann M., Schweikard A., Maehle E. Towards a parameterizable exoskeleton for training of hand function after stroke. IEEE Int Conf Rehabil Robot 2013; http://dx.doi.org/10.1109/ICORR.2013.6650505.
84. Martinez J.A., Ng P., Lu S., Campagna M.S., Celik O. Design of Wrist Gimbal: a forearm and wrist exoskeleton for stroke rehabilitation. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650459.
85. Tang Z., Sugano S., Iwata H. A finger exoskeleton for rehabilitation and brain image study. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650446.
86. Ockenfeld C., Tong R.K., Susanto E.A., Ho S.K., Hu X.L. Fine finger motor skill training with exoskeleton robotic hand in chronic stroke: stroke rehabilitation. IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650392.
87. Aach M., Cruciger O., Sczesny-Kaiser M., Höffken O., Meindl R.Ch., Tegenthoff M., Schwenkreis P., Sankai Y., Schildhauer T.A. Voluntary driven exoskeleton as a new tool for rehabilitation in chronic spinal cord injury: a pilot study. Spine J 2014; 14(12): 2847–2853, http://dx.doi.org/10.1016/j.spinee.2014.03.042.
88. Di Russo F., Berchicci M., Perri R.L., Ripani F.R., Ripani M. A passive exoskeleton can push your life up: application on multiple sclerosis patients. PLoS One 2013; 8(10): e77348, http://dx.doi.org/10.1371/journal.pone.0077348.
89. López N.M., de Diego N., Hernández R., Pérez E., Ensinck G., Valentinuzzi M.E. Customized device for pediatric upper limb rehabilitation in obstetric brachial palsy. Am J Phys Med Rehabil 2014; 93(3): 263–266, http://dx.doi.org/10.1097/PHM.0b013e3182a51c95.
90. Aubin P.M., Sallum H., Walsh C., Stirling L., Correia A. A pediatric robotic thumb exoskeleton for at-home rehabilitation: the Isolated Orthosis for Thumb Actuation (IOTA). IEEE Int Conf Rehabil Robot 2013, http://dx.doi.org/10.1109/ICORR.2013.6650500.
91. Arthrogryposis: a text atlas. Edited by Staheli L.T., Hall J.G., Jaffe K.M., Paholke D.O. Cambridge University Press; 1998.
92. Agras P.I., Guveloglu M., Aydin Y., Yakut A., Kabakus N. Lower brachial plexopathy in a child with Henoch-Schönlein purpura. Pediatr Neurol 2010; 42(5): 355–358, http://dx.doi.org/10.1016/j.pediatrneurol.2010.01.010.
93. Binienda Z.K., Sarkar S., Mohammed-Saeed L., Gough B., Beaudoin M.A., Ali S.F., Paule M.G., Imam S.Z. Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage. Neurosci Lett 2013; 541: 233–237, http://dx.doi.org/10.1016/j.neulet.2013.02.047.
94. Coste B., Houge G., Murray M.F., Stitziel N., Bandell M., Giovanni M.A., Philippakis A., Hoischen A., Riemer G., Steen U., Steen V.M., Mathur J., Cox J., Lebo M., Rehm H., Weiss S.T., Wood J.N., Maas R.L., Sunyaev S.R., Patapoutian A. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 causea subtype of Distal Arthrogryposis. Proc Natl Acad Sci USA 2013; 110(12): 4667–4672, http://dx.doi.org/10.1073/pnas.1221400110.
95. Fleming J., Fogo A., Haider S., Diaz-Cano S., Hay R., Bashir S. Varicella zoster virus brachioplexitis associated with granulomatous vasculopathy. Clin Exp Dermatol 2013; 38(4): 378–381, http://dx.doi.org/10.1111/ced.12096.
96. Kany J., Kumar H.A., Amaravathi R.S., Abid A., Accabled F., de Gauzy J.S., Cahuzac J.P. A subscapularis-preserving arthroscopic release of capsule in the treatment of internal rotation contracture of shoulder in Erb’s palsy (SPARC procedure). J Pediatr Orthop B 2012; 21(5): 469–473, http://dx.doi.org/10.1097/BPB.0b013e328353a19f.
97. van Alfen N. Clinical and pathophysiological concepts of neuralgic amyotrophy. Nat Rev Neurol 2011; 7(6): 315–322, http://dx.doi.org/10.1038/nrneurol.2011.62.
98. Mironenko V.P., Vergunova N.S. Concept of optimal movement model for disabled people. Vestnik Khar’kovskoy gosudarstvennoy akademii dizayna i iskusstv 2014; 3: 20–23.
99. Frolov A.A. Principles of neurorehabilitation based on the usage of “brain-computer” interface and biologically adequate exoskeleton control. Fiziologiya cheloveka 2013; 39(2): 99–113.
100. Leshchenko Ya.A., Batura O.G., Lebedeva L.N. Mortality rate of the working-age population Problemy sotsial’noy gigieny, zdravookhraneniya i istorii meditsiny 2008; 3: 23–25.
101. D’yachenko V.G., Rzyankina M.F., Solokhina L.V. Rukovodstvo po sotsial’noy pediatrii [Manual on the Social Pediatrics]. Khabarovsk; 2010.
102. Ovcharenko S.A. Sotsial’no-gigienicheskaya kharakteristika faktorov riska invalidizatsii naseleniya aktivnogo trudosposobnogo vozrasta. V kn.: Aktual’nye problemy invalidnosti [Social and hygienic characteristics of risk-factors of active working-age population invalidization. In: Actual problems of disability]. Moscow; 2004/1991; p. 48–51.
103. Baranov A.A., Shcheplyagina L.A., Il’in A.G. Cildren health condition as a national security factor. Rossiyskiy pediatricheskiy zhurnal 2005; 2: 4–8.
104. Baranov A.A. Current scientific and practical problems of Russian Pediatrics. Pediatriya 2005; 3: 4–7.
105. Balashova L.M. Analysis of strategies, used in the rehabilitation process by the families, bringing-up disabled children. Izvestiya Rossiyskogo gosudarstvennogo pedagogicheskogo universiteta im. A.I. Gertsena: Aspirantskie tetradi 2007; 17(43-2): 23–26.
106. Astur N., Flynn J.M., Flynn J.M., Ramirez N., Glotzbecker M., van Bosse H.J., Hoashi J.S., d’Amato C.R., Kelly D.M., Warner W.C. Jr., Sawyer J.R. The efficacy of rib-based distraction with VEPTR in the treatment of early-onset scoliosis in patients with arthrogryposis. J Pediatr Orthop 2014; 34(1): 8–13, http://dx.doi.org/10.1097/BPO.0b013e3182a00667.
107. Solov’eva K.S., Bityukov K.A. Problema detskoy invalidnosti v svyazi s ortopedicheskoy patologiey i zadachi ortopeda pri provedenii meditsinskoy reabilitatsii. V kn.: Optimal’nye tekhnologii diagnostiki i lecheniya v detskoy travmatologii i ortopedii, oshibki i oslozhneniya [The problem of children disability related to orthopedic pathology and orthopedist’s tasks in the course of medical rehabilitation. In: Optimal technologies of diagnosis and treatment in pediatric traumatology and orthopedics, errors and complications]. Saint Petersburg; 2003; p. 13–16.
108. Makarova M.R., Lyadov K.V., Turova E.A., Kochetkov A.V. Feasibilities of modern mechanotherapy in the correction of movement disorders in neurological patients. Vestnik vosstanovitel’noy meditsiny 2014; 1: 54–62.

Vorobyev A.A., Petrukhin A.V., Zasypkina O.A., Krivonozhkina P.S., Pozdnyakov A.M. Exoskeleton as a New Means in Habilitation and Rehabilitation of Invalids (Review). Sovremennye tehnologii v medicine 2015; 7(2): 185, https://doi.org/10.17691/stm2015.7.2.22