Prosthetic Repair of the Abdominal Wall Using Light and Ultra-Light Synthetic and Titan-Containing Materials in High Bacterial Contamination (Experimental Study)

The aim of the investigation was to study the course of the reparative process in the early postoperative period after the abdominal wall prosthetic repair using light and ultra-light materials in bacterial contamination in experiment.

Materials and Methods. Retromuscular abdominal wall repair was modeled on rats using light (ultra-light) endoprostheses contaminated by Staphylococcus aureus and Escherichia coli in the Central Research Laboratory of Nizhny Novgorod State Medical Academy. The course of the early postoperative period has been studied, characteristic features of the inflammatory reaction depending on the microorganism cultures and mesh used have been evaluated with the help of the original rating scale.

Results. Prosthetic repair in bacterial contamination in experiment is accompanied by a marked inflammatory reaction. Changes are statistically more significant after infecting by E. coli culture. The most intensive inflammation is observed on day 3 (S. aureus) and day 5 (E. coli) after the intervention with the regression of the process by day 14. On day 3‒7 after the operation in group E. coli the inflammatory reaction was more expressed after TiMesh implantation relative to PP Light application, whereas in group S. aureus it was more significant in case of PP Light application.

Conclusion. Using light and ultra-light mesh in a compromised area of surgical intervention in abdominal wall prosthetic repair is possible by stringent indications taking into account potential usefulness and high risk, possessing adequate experience, and observing a number of conditions. Endoprosthesis should not be placed in contact with the zone of maximum contamination.

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Parshikov V.V., Mironov A.A., Anikina E.A., Zaslavskaya M.I., Alyokhin A.I., Kazantsev A.A. Prosthetic Repair of the Abdominal Wall Using Light and Ultra-Light Synthetic and Titan-Containing Materials in High Bacterial Contamination (Experimental Study). Sovremennye tehnologii v medicine 2015; 7(4): 64, https://doi.org/10.17691/stm2015.7.4.08