Intraoperational Thermal Control of Perifocal Edema in Photodynamic Therapy of Malignant Brain Tumors

The aim of the investigation was to assess the role of infrared imaging for brain tissue heating when exposed to laser radiation in photodynamic therapy of removed tumor bed brain, and its effect on postoperative edema.

Materials and Methods. We studied the treatment results of 20 patients with malignant brain tumors with intraoperative photodynamic therapy (PDT). The patients were divided into two groups: the study group (n=12) had intraoperative infrared imaging (IRI)-guided PDT, and the control group patients (n=8) had no IRI control.

Results. Perifocal edema in the study group on the first postoperative day decreased, and was 50.4 [16.4; 79.3] and 88.5 [30.3; 110.6]% of preoperative values according to axial and coronary section study. In the control group postoperative edema increased and was 227.9 [92.4; 303.8] and 154.7 [84.5; 150.3]% of the initial.

Conclusion. PDT is accompanied by temperature rise of the exposed tissues, and increased perifocal edema in an early postoperative period. IRI control of exposed tissues heating in PDT of tumor bed enables to avoid edema augmentation of surrounding brain tissues.

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