Role of Iodine Deficiency in the Development of Menstrual Disorders in Young Females
The aim of the investigation was to study the effect of iodine level in young females on the development of menstrual disorders.
Materials and Methods. We determined iodine content in urine by a potentiometric method using ion-selective electrodes to analyze iodide ions. Due to the high amplitude vibrations of individual iodine concentrations in urine (ioduria) to estimate the severity of iodine deficiency, we used a mean iodine concentration in urine — a median.
Results. The content of urinary iodine excretion in young females with menstrual function disorders ranged widely from 18 to 109 µg/L. The median of iodine excretion appeared to be lower than the existing standards, and was 74.8 µg/L.
We revealed the positive direct relations between ioduria and impaired menstrual function (r=0.46). To assess the effectiveness of the program of iodine deficiency prevention of menstrual function in young girls 5–6 months after iodine administration, we re-evaluated their iodine level. The number of normal findings of urinary iodine excretions was found to have increased up to 70.6% cases, neither moderate nor severe iodine deficiencies being revealed. Moreover, most young females with menstrual disorders were found to have improved functioning of the reproductive system.
- Klinicheskaya endokrinologiya [Clinical endocrinology]. Pod red. Kholodovoy E.A. [Kholodova E.A. (editor)]. Moscow: Meditsinskoe informatsionnoe agentstvo; 2011; 736 p.
- Serov V.N., Prilepskaya V.N., Ovsyannikova T.V. Ginekologicheskaya endokrinologiya [Gynecological endocrinology]. M: MEDpressiform; 2008; 528 p.
- World Health Organization. International Council for the Control of the Iodine Deficiency Disorders. United Nations Children`s Fund (WHO/ICCIDD/UNICEF). Assessment of the iodine deficiency disorders and monitoring their elimination. 3rd Edition. Geneva: World Health Organization; 2008.
- Leung A.M., LaMar A., He X., Braverman L.E., Pearce E.N. Iodine status and thyroid function of Boston-area vegetarians and vegans. J Clin Endocrinol Metab 2011; 96(8): E1303–E1307, https://doi.org/10.1210/jc.2011-0256.
- Dedov I.I., Melnichenko G.A., Troshina E.A., et al. Defitsit yoda — ugroza zdorov’yu i razvitiyu detey Rossii. Puti resheniya problem Natsional’nyy doklad [Iodine deficiency — a threat to the health and development of children in Russia. Ways of solving the problem. National report]. M; 2006.
- Ara G., Melse-Boon A., Roy S.K., Alam N., Ahmed S., Khatun U.H.F., Ahmed T. Sub-clinical iodine deficiency still prevalent in bangladeshi adolescent girls and pregnant women. Asian J Clin Nutr 2010; 2(1): 1–12, https://doi.org/10.3923/ajcn.2010.1.12.
- Assey V.D., Greiner T., Mzee R.K., Abuu H., Mgoba C., Kimboka S., Peterson S. Iodine deficiency persists in the Zanzibar islands of Tanzania. Food Nutr Bull 2006; 27(4): 292–299, https://doi.org/10.1177/156482650602700402.
- Pearce E.N., Pino S., He X., Bazrafshan H.R., Lee S.L., Braverman L.E. Sources of dietary iodine: bread, cows’ milk, and infant formula in the Boston area. J Clin Endocrinol Metab 2004; 89(7): 3421–3424, https://doi.org/10.1210/jc.2003-032002.
- Morreale de Escobar G., Obregon M., Escobar del Rey F. Role of thyroid hormone during early brain development. Eur J Endocrinol 2004; 151(Suppl_3): U25–U37, https://doi.org/10.1530/eje.0.151u025.
- Ausó E., Lavado-Autric R., Cuevas E., del Rey F.E., Morreale de Escobar G., Berbel P. A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology 2004; 145(9): 4037–4047, https://doi.org/10.1210/en. 2004-0274.
- Koibuchi N., Chin W.W. Thyroid hormone action and brain development. Trends Endocrinol Metab 2000; 11(4): 123–128, https://doi.org/10.1016/s1043-2760(00)00238-1.
- Chan S. Thyroid hormone and central nervous system development. J Endocrinol 2000; 165(1): 1–8, https://doi.org/10.1677/joe.0.1650001.
- Delange F. Endemic cretinism. In: The thyroid. A fundamental and clinical text. Braverman L.E., Utiger R.D. (editors). Philadelphia: J.B. Lippincott; 1996; p. 756–767.
- Glinoer D., Delange F. The Potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny. Thyroid 2000; 10(10): 871–887, https://doi.org/10.1089/thy.2000.10.871.
- Santiago-Fernandez P., Torres-Barahona R., Muela-Martínez J.A., Rojo-Martínez G., García-Fuentes E., Garriga M.J., León A.G., Soriguer F. Intelligence quotient and iodine intake: a cross-sectional study in children. J Clin Endocrinol Metab 2004; 89(8): 3851–3857, https://doi.org/10.1210/jc.2003-031652.
- Zimmermann M.B., Connolly K., Bozo M., Bridson J., Rohner F., Grimci L. Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. Am J Clin Nutr 2006; 83(1): 108–114.