Monitoring of Myocardial Energy Metabolism as an Early Marker of Life Threatening Conditions

The aim of the investigation was to verify early signs of heart failure decompensation and its progression in cardiosurgical patients according to the dynamics of myocardial energy metabolism indices.

Materials and Methods. We examined 80 cardiosurgical patients, who had undergone artificial circulation surgeries in Nizhny Novgorod Specialized Cardiac Surgery Clinical Hospital. A control group consisted of 40 healthy volunteers. The concentration of glucose and high-energy compounds was determined by infrared spectroscopy of blood serum in the absorption band 1,200–1,000 cm^–1, typical for phosphorus-containing compounds and glucose. To verify the concentration dynamics of fatty acids, gas chromatography was used.

Results. The study revealed the regularity of occurrence of life threatening conditions caused by changed direction of myocardial energy metabolism: the accumulation of glucose and fatty acids in blood serum due to reduced glycolysis rate and intensity, and lipolysis caused by myocardial oxygen deprivation and accompanying concentration change of high-energy compounds.

Conclusion. In heart failure decompensation and tissue hypoxia in myocardial cells there is the decrease of glycolysis and lipolysis rate resulting in an increased concentration of glucose and fatty acids against a decreased concentration of adenosine triphosphoric acid that still aggravates myocardial dysfunction and ischemia. The changes can serve as the early markers of life threatening conditions.

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Krasnikova О.V., Petrova I.А., Nemirova S.V., Medvedev А.P., Shakhov B.Е., Gordetsov А.S. Monitoring of Myocardial Energy Metabolism as an Early Marker of Life Threatening Conditions. Sovremennye tehnologii v medicine 2017; 9(1): 149, https://doi.org/10.17691/stm2017.9.1.19