Today: Dec 26, 2024
RU / EN
Last update: Oct 30, 2024
Synthetic Cathinones and Cannabinoids Are New Psychoactive Substances (Review)

Synthetic Cathinones and Cannabinoids Are New Psychoactive Substances (Review)

Larchenko А.V., Suvorov M.А., Andryukhin V.I., Kaurov Ya.V., Suvorov А.V.
Key words: new psychoactive substances; synthetic cathinones; bath salts; mephedrone; synthetic cannabinoids; spice.
2017, volume 9, issue 1, page 185.

Full text

html pdf
14775
7663

New psychoactive substances, or designer drugs, are currently a large group of substances, primarily of synthetic origin, which are designed and come on a shadow market in circumvention of the current law. The popularity of these substances among young people is due to the off-the-shelf availability, low cost, and expected safety compared to traditional drugs. As practice shows, a resulting intoxication is life-threatening.

Currently, the ordered data on these substances classes, as well as clinical manifestations of poisoning related to their consumption is practically non-existent due to certain difficulties in their diagnosis. The review considers the main groups of new psychoactive substances (synthetic cathinones and cannabinoids, derivatives of piperazine, aminoindans) circulating in a shadow market. We have distinguished the basic mechanisms of their effect on human body and described the main manifestations of their consumption.

When writing the review we used the data of specialized poison control medical centers, as well as the information obtained from users.

  1. Carroll F.I., Lewin A.H., Mascarella S.W., Seltzman H.H., Reddy P.A. Designer drugs: a medicinal chemistry perspective. Ann N Y Acad Sci 2011; 1248(1): 18–38, https://doi.org/10.1111/j.1749-6632.2011.06199.x.
  2. Nobis F. “Legal-High”-Produkte — wirklich illegal? Oder: wie ein Aufsatz sich verselbstständigt. NStZ 2012; 422.
  3. Europäische Beobachtungsstelle für Drogen und Drogensucht. Europäischer Drogenbericht. Trends und Entwicklungen. Luxemburg: Amt für Veröffentlichungen der Europäischen Union, 2013. URL: http://www.emcdda.europa.eu/attachements.cfm/att_213154_DE_TDAT13001DEN1.pdf.
  4. Fattore L., Fratta W. Beyond THC: the new generation of cannabinoid designer drugs. Front Behav Neurosci 2011; 5: 60, https://doi.org/10.3389/fnbeh.2011.00060.
  5. Rosenbaum C.D., Carreiro S.P., Babu K.M. Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. J Med Toxicol 2012; 8(1): 15–32, https://doi.org/10.1007/s13181-011-0202-2.
  6. Meyer M.R., Wilhelm J., Peters F.T., Maurer H.H. Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry. Anal Bioanal Chem 2010; 397(3): 1225–1233, https://doi.org/10.1007/s00216-010-3636-5.
  7. Kneisel S., Auwärter V., Kempf J. Analysis of 30 synthetic cannabinoids in oral fluid using liquid chromatography-electrospray ionization tandem mass spectrometry. Drug Test Anal 2012; 5(8): 657–669, https://doi.org/10.1002/dta.1429.
  8. Kaurov Y.V., Larchenko A.V., Artyomenko A.G., Gnelitsky G.I., Mudrova S.A., Pankov A.V. Smoking mixture: medical and social aspects. Zdorov’e i obrazovanie v ХХI veke 2014; 16(4): 162–164.
  9. James D., Adams R.D., Spears R., Cooper G., Lupton D.J., Thompson J.P., Thomas S.H.; National Poisons Information Service. Clinical characteristics of mephedrone toxicity reported to the UK National Poisons Information Service. Emerg Med J 2010; 28(8): 686–689, https://doi.org/10.1136/emj.2010.096636.
  10. Bernard C., Werse B., Schell-Mack C. MoSyD. JAHRESBERICHT 2012. Drogentrends in Frankfurt am Main. Centre for Drug Research; 2013. URL: https://www.uni-frankfurt.de/51782964/MoSyD-Jahresbericht-2012.pdf.
  11. Hermanns-Clausen M., Kneisel S., Szabo B., Auwärter V. Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings. Addiction 2012; 108(3): 534–544, https://doi.org/10.1111/j.1360-0443.2012.04078.x.
  12. Musshoff F., Madea B., Kernbach-Wighton G., Bicker W., Kneisel S., Hutter M., Auwärter V. Driving under the influence of synthetic cannabinoids (“Spice”): a case series. Int J Legal Med 2013; 128(1): 59–64, https://doi.org/10.1007/s00414-013-0864-1.
  13. Zimmermann U.S., Winkelmann P.R., Pilhatsch M., Nees J.A., Spanagel R., Schulz K. Withdrawal phenomena and dependence syndrome after the consumption of “spice gold”. Dtsch Arztebl Int 2009; 106(27): 464–467.
  14. Winstock A.R., Mitcheson L.R., Deluca P., Davey Z., Corazza O., Schifano F. Mephedrone, new kid for the chop? Addiction 2011; 106(1): 154–161, https://doi.org/10.1111/j.1360-0443.2010.03130.x.
  15. Dargan P.I., Albert S., Wood D.M. Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change. QJM 2010; 103(11): 875–879, https://doi.org/10.1093/qjmed/hcq134.
  16. Kriikku P., Wilhelm L., Schwarz O., Rintatalo J. New designer drug of abuse: 3,4-methylenedioxypyrovalerone (MDPV). Findings from apprehended drivers in Finland. Forensic Sci Int 2011; 210(1–3): 195–200, https://doi.org/10.1016/j.forsciint.2011.03.015.
  17. Winstock A., Mitcheson L., Marsden J. Mephedrone: still available and twice the price. Lancet 2010; 376(9752): 1537, https://doi.org/10.1016/s0140-6736(10)62021-1.
  18. Centers for Disease Control and Prevention (CDC). Emergency department visits after use of a drug sold as “bath salts”. Michigan, November 13, 2010–March 31, 2011. MMWR Morb Mortal Wkly Rep 2011; 60(19): 624–627.
  19. Glennon R.A., Yousif M., Naiman N., Kalix P. Methcathinone: a new and potent amphetamine-like agent. Pharmacol Biochem Behav 1987; 26(3): 547–551, https://doi.org/10.1016/0091-3057(87)90164-x.
  20. Graziani M., Milella M.S., Nencini P. Khat chewing from the pharmacological point of view: an update. Subst Use Misuse 2008; 43(6): 762–783, https://doi.org/10.1080/10826080701738992.
  21. Al-Motarreb A., Al-Habori M., Broadley K.J. Khat chewing, cardiovascular diseases and other internal medical problems: The current situation and directions for future research. J Ethnopharmacol 2010; 132(3): 540–548, https://doi.org/10.1016/j.jep.2010.07.001.
  22. Kelly J.P. Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. Drug Test Anal 2011; 3(7–8): 439–453, https://doi.org/10.1002/dta.313.
  23. Emerson T.S., Cisek J.E. Methcathinone: A Russian designer amphetamine infiltrates the rural midwest. Ann Emerg Med 1993; 22(12): 1897–1903, https://doi.org/10.1016/s0196-0644(05)80419-6.
  24. Goldberg J., Gardos G., Cole J.O. A controlled evaluation of pyrovalerone in chronically fatigued volunteers. Int Pharmacopsychiatry 1973; 8(1): 60–69.
  25. Karila L., Reynaud M. GHB and synthetic cathinones: clinical effects and potential consequences. Drug Testing and Analysis 2010; 3(9): 552–559, https://doi.org/10.1002/dta.210.
  26. Baron M., Elie M., Elie L. An analysis of legal highs-do they contain what it says on the tin? Drug Test Anal 2011; 3(9): 576–581, https://doi.org/10.1002/dta.274.
  27. King’s College London. Institute of psychiatry. Psychonaut Web Mapping Research Group. Spice report. London, UK; 2009.
  28. Wood K.E. Exposure to bath salts and synthetic tetrahydrocannabinol from 2009 to 2012 in the United States. J Pediatr 2013; 163(1): 213–216, https://doi.org/10.1016/j.jpeds.2012.12.056.
  29. Spiller H.A., Ryan M.L., Weston R.G., Jansen J. Clinical experience with and analytical confirmation of “bath salts” and “legal highs” (synthetic cathinones) in the United States. Clinical Toxicology 2011; 49(6): 499–505, https://doi.org/10.3109/15563650.2011.590812.
  30. Maxwell J.C. Psychoactive substances — some new, some old: a scan of the situation in the U.S. Drug Alcohol Depend 2014; 134: 71–77, https://doi.org/10.1016/j.drugalcdep.2013.09.011.
  31. Simmler L.D., Buser T.A., Donzelli M., Schramm Y., Dieu L.H., Huwyler J., Chaboz S., Hoener M.C., Liechti M.E. Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol 2012; 168(2): 458–470, https://doi.org/10.1111/j.1476-5381.2012.02145.x.
  32. Zawilska J.B., Wojcieszak J. Designer cathinones — an emerging class of novel recreational drugs. Forensic Sci Int 2013; 231(1–3): 42–53, https://doi.org/10.1016/j.forsciint.2013.04.015.
  33. Carhart-Harris R.L., King L.A., Nutt D.J. A web-based survey on mephedrone. Drug Alcohol Depend 2011; 118(1): 19–22, https://doi.org/10.1016/j.drugalcdep.2011.02.011.
  34. Newcombe R. Mephedrone: the use of mephedrone (M-cat, meow) in Middlesbrough. Manchester, UK: Lifeline Publications; 2009.
  35. Advisory Council on the Misuse of Drugs. Consideration of the cathinones. 2010. URL: http://www.namsdl.org/library/E2E84A68-1372-636C-DD0E8D3A508B5F48/ .
  36. Wood D.M., Davies S., Puchnarewicz M., Button J., Archer R., Ovaska H., Ramsey J., Lee T., Holt D.W., Dargan P.I. Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicity. J Med Toxicol 2010; 6(3): 327–330, https://doi.org/10.1007/s13181-010-0018-5.
  37. Dargan P., Wood D. Technical report on mephedrone. In: EMCDDA. Risk assessments. Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances. Lisbon; 2011; p. 49–102.
  38. Schifano F., Albanese A., Fergus S., Stair J.L., Deluca P., Corazza O., Davey Z., Corkery J., Siemann H., Scherbaum N., Farre’ M., Torrens M., Demetrovics Z., Ghodse A.H.; Psychonaut Web Mapping; ReDNet Research Groups. Mephedrone (4-methylmethcathinone; “meow meow”): chemical, pharmacological and clinical issues. Psychopharmacology 2010; 214(3): 593–602, https://doi.org/10.1007/s00213-010-2070-x.
  39. Brunt T.M., Poortman A., Niesink R.J., van den Brink W. Instability of the ecstasy market and a new kid on the block: mephedrone. J Psychopharmacol 2011; 25(11): 1543–1547, https://doi.org/10.1177/0269881110378370.
  40. Dickson A.J., Vorce S.P., Levine B., Past M.R. Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. J Anal Toxicol 2010; 34(3): 162–168, https://doi.org/10.1093/jat/34.3.162.
  41. Maskell P.D., De Paoli G., Seneviratne C., Pounder D.J. Mephedrone (4-methylmethcathinone)-related deaths. J Anal Toxicol 2011; 35(3): 188–191, https://doi.org/10.1093/anatox/35.3.188.
  42. Torrance H., Cooper G. The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland. Forensic Sci Int 2010; 202(1–3): e62–e63, https://doi.org/10.1016/j.forsciint.2010.07.014.
  43. Ross E.A., Watson M., Goldberger B. “Bath Salts” intoxication. N Engl J Med 2011; 365(10): 967–968, https://doi.org/10.1056/nejmc1107097.
  44. Freeman T.P., Morgan C.J.A., Vaughn-Jones J., Hussain N., Karimi K., Curran H.V. Cognitive and subjective effects of mephedrone and factors influencing use of a “new legal high”. Addiction 2012; 107(4): 792–800, https://doi.org/10.1111/j.1360-0443.2011.03719.x.
  45. Belton P., Sharngoe T., Maguire F.M., Polhemus M. Cardiac infection and sepsis in 3 intravenous bath salts drug users. Clin Infect Dis 2013; 56(11): e102–e104, https://doi.org/10.1093/cid/cit095.
  46. Penders T.M., Gestring R.E., Vilensky D.A. Excited delirium following use of synthetic cathinones (bath salts). Gen Hosp Psychiatry 2012; 34(6): 647–650, https://doi.org/10.1016/j.genhosppsych.2012.06.005.
  47. Nicholson P.J., Quinn M.J., Dodd J.D. Headshop heartache: acute mephedrone ‘meow’ myocarditis. Heart 2010; 96(24): 2051–2052, https://doi.org/10.1136/hrt.2010.209338.
  48. Loeffler G., Penn A., Ledden B. “Bath salt”-induced agitated paranoia: a case series. J Stud Alcohol Drugs 2012; 73(4): 706–706, https://doi.org/10.15288/jsad.2012.73.706.
  49. Borek H.A., Holstege C.P. Hyperthermia and multiorgan failure after abuse of “bath salts” containing 3,4-methylenedioxypyrovalerone. Ann Emerg Med 2012; 60(1): 103–105, https://doi.org/10.1016/j.annemergmed.2012.01.005.
  50. Regan L., Mitchelson M., Macdonald C. Mephedrone toxicity in a Scottish emergency department. Emerg Med J 2010; 28(12): 1055–1058, https://doi.org/10.1136/emj.2010.103093.
  51. Henry J.A., Fallon J.K., Kicman A.T., Hutt A.J., Cowan D.A., Forsling M. Low-dose MDMA (“ecstasy”) induces vasopressin secretion. Lancet 1998; 351(9118): 1784, https://doi.org/10.1016/s0140-6736(05)78744-4.
  52. Wood D.M., Davies S., Greene S.L., Button J., Holt D.W., Ramsey J., Dargan P.I. Case series of individuals with analytically confirmed acute mephedrone toxicity. Clin Toxicol (Phila) 2010; 48(9): 924–927, https://doi.org/10.3109/15563650.2010.531021.
  53. Fröhlich S., Lambe E., O’Dea J. Acute liver failure following recreational use of psychotropic “head shop” compounds. Ir J Med Sci 2010; 180(1): 263–264, https://doi.org/10.1007/s11845-010-0636-6.
  54. Winstock A., Mitcheson L., Ramsey J., Davies S., Puchnarewicz M., Marsden J. Mephedrone: use, subjective effects and health risks. Addiction 2011; 106(11): 1991–1996, https://doi.org/10.1111/j.1360-0443.2011.03502.x.
  55. Shimizu E., Watanabe H., Kojima T., Hagiwara H., Fujisaki M., Miyatake R., Hashimoto K., Iyo M. Combined intoxication with methylone and 5-MeO-MIPT. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(1): 288–291, https://doi.org/10.1016/j.pnpbp.2006.06.012.
  56. Sammler E.M., Foley P.L., Lauder G.D., Wilson S.J., Goudie A.R., O’Riordan J.I. A harmless high? Lancet 2010; 376(9742): 742, https://doi.org/10.1016/s0140-6736(10)60891-4.
  57. Gustavsson D., Escher C. Mephedrone — internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance. Lakartidningen 2009; 106(43): 2769–2771.
  58. Schifano F., Corkery J., Ghodse A.H. Suspected and confirmed fatalities associated with mephedrone (4-methylmethcathinone, “meow meow”) in the United Kingdom. J Clin Psychopharmacol 2012; 32(5): 710–714, https://doi.org/10.1097/jcp.0b013e318266c70c.
  59. Wikstrom M., Thelander G., Nystrom I., Kronstrand R. Two fatal intoxications with the new designer drug methedrone (4-methoxymethcathinone). J Anal Toxicol 2010; 34(9): 594–598, https://doi.org/10.1093/jat/34.9.594.
  60. Carter N., Rutty G.N., Milroy C.M., Forrest A.R.W. Deaths associated with MBDB misuse. Int J Legal Med 2000; 113(3): 168–170, https://doi.org/10.1007/s004140050291.
  61. Harbert C.A., Johnson M.R., Melvin L.S.Jr. 3-[Hydroxy-4-(substituted)-phenyl]-cycloalkanone and cycloalkanol derivatives. DE Patent 2839836. 1979.
  62. Weissman A., Milne G.M., Melvin L.S. Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. J Pharmacol Exp Ther 1982; 223(2): 516–523.
  63. Little P.J., Compton D.R., Mechoulam R., Martin B.R. Stereochemical effects of 11-OH-Δ8-THC-dimethylheptyl in mice and dogs. Pharmacol Biochem Behav 1989; 32(3): 661–666, https://doi.org/10.1016/0091-3057(89)90014-2.
  64. Mechoulam R., Feigenbaum J.J., Lander N., Segal M., Järbe T.U.C., Hiltunen A.J., Consroe P. Enantiomeric cannabinoids: stereospecificity of psychotropic activity. Experientia 1988; 44(9): 762–764, https://doi.org/10.1007/bf01959156.
  65. Howlett A.C., Barth F., Bonner T.I., Cabral G., Casellas P., Devane W.A., Felder C.C., Herkenham M., Mackie K., Martin B.R., Mechoulam R., Pertwee R.G. International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors. Pharmacol Rev 2002; 54(2): 161–202, https://doi.org/10.1124/pr.54.2.161.
  66. Crippa J.A., Zuardi A.W., Hallak J.E. Therapeutical use of the cannabinoids in psychiatry. Rev Bras Psiquiatr 2010; 32(Suppl 1): S56–66.
  67. Escobar-Chávez J.J., Domínguez-Delgado C.L., Rodríguez-Cruz I.M. Targeting nicotine addiction: the possibility of a therapeutic vaccine. Drug Des Devel Ther 2011; 211, https://doi.org/10.2147/dddt.s10033.
  68. Justinova Z., Panlilio L.V., Goldberg S.R. Drug addiction. Curr Top Behav Neurosci 2009; 309–346, https://doi.org/10.1007/978-3-540-88955-7_13.
  69. Fernández-Ruiz J., Moreno-Martet M., Rodríguez-Cueto C., Palomo-Garo C., Gómez-Cañas M., Valdeolivas S., Guaza C., Romero J., Guzmán M., Mechoulam R., Ramos J.A. Prospects for cannabinoid therapies in basal ganglia disorders. Br J Pharmacol 2011; 163(7): 1365–1378, https://doi.org/10.1111/j.1476-5381.2011.01365.x.
  70. Sánchez A.J., García-Merino A. Neuroprotective agents: Cannabinoids. Clin Immunol 2012; 142(1): 57–67, https://doi.org/10.1016/j.clim.2011.02.010.
  71. Howlett A.C., Breivogel C.S., Childers S.R., Deadwyler S.A., Hampson R.E., Porrino L.J. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology 2004; 47: 345–358, h ttps://doi.org/10.1016/j.neuropharm.2004.07.030.
  72. Centers for Disease Control and Prevention. Acute kidney injury associated with synthetic cannabinoid use — multiple states 2012. MMWR Morb Mortal Wkly Rep 2013; 62: 93–98.
  73. Auwärter V., Dresen S., Weinmann W., Müller M., Pütz M., Ferreirós N. “Spice” and other herbal blends: harmless incense or cannabinoid designer drugs? J Mass Spectrom 2009; 44(5): 832–837, https://doi.org/10.1002/jms.1558.
  74. Seely K.A., Prather P.L., James L.P., Moran J.H. Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? Mol Interv 2011; 11(1): 36–51.
  75. Simolka K., Lindigkeit R., Schiebel H.-M., Papke U., Ernst L., Beuerle T. Analysis of synthetic cannabinoids in “spice-like” herbal highs: snapshot of the German market in summer 2011. Anal Bioanal Chem 2012; 404(1): 157–171, https://doi.org/10.1007/s00216-012-6122-4.
  76. Hillebrand J., Olszewski D., Sedefov R. Legal highs on the internet. Subst Use Misuse 2010; 45(3): 330–340, https://doi.org/10.3109/10826080903443628.
  77. Randall M.D., Kendall D.A., O’Sullivan S. The complexities of the cardiovascular actions of cannabinoids. Br J Pharmacol 2004; 142(1): 20–26, https://doi.org/10.1038/sj.bjp.0705725.
  78. Atwood B.K., Huffman J., Straiker A., Mackie K. JWH018, a common constituent of “Spice” herbal blends, is a potent and efficacious cannabinoid CB 1 receptor agonist. Br J Pharmacol 2010; 160(3): 585–593, https://doi.org/10.1111/j.1476-5381.2009.00582.x.
  79. Psychoyos D., Vinod K.Y. Marijuana, Spice ‘herbal high’, and early neural development: implications for rescheduling and legalization. Drug Test Anal 2013; 5(1): 27–45, https://doi.org/10.1002/dta.1390.
  80. Griffiths P., Sedefov R., Gallegos A., Lopez D. How globalization and market innovation challenge how we think about and respond to drug use: “Spice” a case study. Addiction 2010; 105(6): 951–953, https://doi.org/10.1111/j.1360-0443.2009.02874.x.
  81. Forrester M.B. Synthetic cathinone exposures reported to Texas poison centers. Am J Drug Alcohol Abuse 2012; 38(6): 609–615, https://doi.org/10.3109/00952990.2012.677890.
  82. Gunderson E.W., Haughey H.M., Ait-Daoud N., Joshi A.S., Hart C.L. “Spice” and “K2” herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans. Am J Addict 2012; 21(4): 320–326, https://doi.org/10.1111/j.1521-0391.2012.00240.x.
  83. Müller H., Sperling W., Köhrmann M., Huttner H.B., Kornhuber J., Maler J.-M. The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes. Schizophr Res 2010; 118(1–3): 309–310, https://doi.org/10.1016/j.schres.2009.12.001.
  84. De Boer D., Bosman I.J., Hidvégi E., Manzoni C., Benkö A.A., dos Reys L.J.A., Maes R.A. Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market. Forensic Sci Int 2001; 121(1–2): 47–56, https://doi.org/10.1016/s0379-0738(01)00452-2.
  85. Elliott S. Current awareness of piperazines: pharmacology and toxicology. Drug Test Anal 2011; 3(7–8): 430–438, https://doi.org/10.1002/dta.307.
  86. Thompson I., Williams G., Caldwell B., Aldington S., Dickson S., Lucas N., McDowall J., Weatherall M., Robinson G., Beasley R. Randomised double-blind, placebo-controlled trial of the effects of the “party pills” BZP/TFMPP alone and in combination with alcohol. J Psychopharmacol 2010; 24(9): 1299–1308, https://doi.org/10.1177/0269881109102608.
  87. Gee P., Gilbert M., Richardson S., Moore G., Paterson S., Graham P. Toxicity from the recreational use of 1-benzylpiperazine. Clin Toxicol (Phila) 2008; 46(9): 802–807, https://doi.org/10.1080/15563650802307602.
  88. Coppola M., Mondola R. 5-Iodo-2-aminoindan (5-IAI): chemistry, pharmacology, and toxicology of a research chemical producing MDMA-like effects. Toxicol Lett 2013; 218(1): 24–29, https://doi.org/10.1016/j.toxlet.2013.01.008.
  89. Sainsbury P.D., Kicman A.T., Archer R.P., King L.A., Braithwaite R.A. Aminoindanes-the next wave of “legal highs”? Drug Test Anal 2011; 3(7–8): 479–482, https://doi.org/10.1002/dta.318.
  90. Corkery J.M., Elliott S., Schifano F., Corazza O., Ghodse A.H. MDAI (5,6-methylenedioxy-2-aminoindane; 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine; “sparkle”; “mindy”) toxicity: a brief overview and update. Hum Psychopharmacol 2013; 28(4): 345–355, https://doi.org/10.1002/hup.2298.
  91. Corazza O., Schifano F., Farre M., Deluca P., Davey Z., Torrens M., Demetrovics Z., Di Furia L., Flesland L., Siemann H., Skutle A., Van Der Kreeft P., Scherbaum N. Designer drugs on the internet: a phenomenon out-of-control? The emergence of hallucinogenic drug bromo-dragonfly. Curr Clin Pharmacol 2011; 6(2): 125–129, https://doi.org/10.2174/157488411796151129.
  92. King’s College London. Institute of psychiatry. Psychonaut Web Mapping Research Group. Bromo-dragonfly report. London, UK; 2009.
  93. Thorlacius K., Borna C., Personne M. Bromo-dragon fly — life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case. Lakartidningen 2008; 105916): 1199–1200.
  94. Federal’nyy zakon Rossiyskoy Federatsii ot 3 fevralya 2015 g. №7-FZ “O vnesenii izmeneniy v otdel’nye zakonodatel’nye akty Rossiyskoy Federatsii” [Federal Law of the Russian Federation dated February 3, 2015 No.7-FL “Concerning the Introduction of Amendments to Certain Legislative Acts”].
  95. Federal’nyy zakon ot 8 yanvarya 1998 goda №3-FZ “O narkoticheskikh sredstvakh i psikhicheskikh veshchestvakh” [Federal Law dated January 8, 1998 No.3-FL “Concerning Narcotics and Psychotropic Substances”].

Larchenko А.V., Suvorov M.А., Andryukhin V.I., Kaurov Ya.V., Suvorov А.V. Synthetic Cathinones and Cannabinoids Are New Psychoactive Substances (Review). Sovremennye tehnologii v medicine 2017; 9(1): 185, https://doi.org/10.17691/stm2017.9.1.23


Journal in Databases

pubmed_logo.jpg

web_of_science.jpg

scopus.jpg

crossref.jpg

ebsco.jpg

embase.jpg

ulrich.jpg

cyberleninka.jpg

e-library.jpg

lan.jpg

ajd.jpg

SCImago Journal & Country Rank