Today: Dec 6, 2024
RU / EN
Last update: Oct 30, 2024
Physicochemical Properties of Intravitreal Implant Based on Chitosan/Polyvinyl Alcohol Saturated with 5-Fluorouracil

Physicochemical Properties of Intravitreal Implant Based on Chitosan/Polyvinyl Alcohol Saturated with 5-Fluorouracil

Baiyrkhanova A.O., Botabekova T.K., Semenova Y.M., Ismailova A.B., Rakhypbekov T.K.
Key words: proliferative vitreoretinopathy; 5-fluorouracil; 5-FU; chitosan; intravitreal implant; chitosan-based implant.
2017, volume 9, issue 3, page 102.

Full text

html pdf
2319
1904

The aim of the investigation was to evaluate the possibility of using intravitreal introduction of the implant based on chitosan-polymer film saturated with 5-fluorouracil.

Materials and Methods. There was performed a study of physicochemical properties of chitosan/polyvinyl alcohol-based implant saturated with 5-fluorouracil (5-FU) in concentrations of 0.05 and 0.1 ml. The implant size was 8.0×1.0×0.35 mm. The process of drug release was studied by UV spectroscopy based on the characteristic absorption maximum. To assess the sterilization ability of chitosan films, their thermal stability was studied. The possibilities of interaction between chemical groups of chitosan, polyvinyl alcohol and 5-FU were studied by analyzing the infrared spectra of these substances.

Results. It was established that the process of drug release from the system occurs in three stages: 1) sorption of water by the film and swelling; 2) the drug diffusing in the film to the interphase boundary between the polymer system and the environment; 3) the drug diffusing into the solvent volume. Release of 5-FU from the implant to Ringer–Locke solution occurs almost completely within 7–8 h without undergoing any change. Thermal degradation of the implant begins at the temperature of 200°C. Infrared spectroscopy data evidence that 5-FU immobilized on chitosan film with polyvinyl alcohol undergoes no chemical changes and, consequently, does not lose its pharmacological properties.

Conclusion. The study of physicochemical properties of chitosan/polyvinyl alcohol-based implant saturated with 5-FU cytostatic proves the feasibility of its use in ophthalmology to reduce the initial peak concentration of 5-FU and, consequently, eliminate its toxic effects and prolong the drug action.

  1. Sosnovskiy S.V., Boyko E.V., Kharitonova N.N. The substantiation and development of the quantative assessment system of the severity of proliferative vitreoretinopathy. Oftal’mokhirurgiya 2009; 4: 25–29.
  2. Il’nitskiy V.V. Vremennoe i postoyannoe episkleral’noe plombirovanie v khirurgii otsloyki setchatki, ee profilaktika. Dis. ... dokt. med. nauk [Temporary and permanent episcleral buckling in retinal detachment surgery and its prevention. DSc Thesis]. Moscow; 1995.
  3. Balinskaya N.R. Kombinirovannye intravitreal’nye khirurgicheskie vmeshatel’stva pri otsloyke setchatki, oslozhnennoy vitreoretinal’noy traktsiey. Dis. ... kand. med. nauk [Combined intravitreous surgery for retinal detachment complicated by vitreoretinal traction. PhD Thesis]. Moscow; 1993.
  4. Kochmala O.B., Zapuskalov I.V., Krivosheina O.I., Dashko I.A. Retinal detachment surgery: state of art. Vestnik oftal’mologii 2010; 126(6): 46–49.
  5. Zakharov V.D. Vitreoretinal’naya khirurgiya [Vitreoretinal surgery]. Moscow: Meditsina; 2003; 180 p.
  6. Zhurgumbaeva G.K. Vitreosineretik «Vitrenal» v khirurgii proliferativnoy vitreoretinopatii pri otsloyke setchatki. Dis. ... kand. med. nauk [Vitreosyneretic Vitrenal in surgery of proliferative vitreoretinopathy in retinal detachment. PhD Thesis]. Almaty; 2009.
  7. Glinchuk Ya.I. Rol’ vitrektomii v lechenii zabolevaniy glaz travmaticheskoy, degenerativnoy i vospalitel’noy etiologii. Dis. … dokt. med. nauk [The role of vitrectomy in treatment of eye diseases of traumatic, degenerative and inflammatory etiology. DSc Thesis]. Moscow; 1987.
  8. Zakharov V.D., Sharipova D.N., Shatskikh A.V. Possibilities of treating proliferative vitreoretinopathy in light of modern aspects of its etiology and pathogenesis. Oftal’mokhirurgiya 2006; 2: 59–65.
  9. Afrashi F., Erakgun T., Akkin C., Kaskaloglu M., Mentes J. Conventional buckling surgery or primary vitrectomy with silicone oil tamponade in rhegmatogenous retinal detachment with multiple breaks. Graefes Arch Clin Exp Ophthalmol 2004; 242(4): 295–300, https://doi.org/10.1007/s00417-003-0842-2.
  10. Christensen U., Villumsen J. Prognosis of pseudophakic retinal detachment. J Cataract Refract Surg 2005; 31(2): 354–358.
  11. Goezinne F., La Heij E.C., Berendschot T.T., Kessels A.G., Liem A.T., Diederen R.M., Hendrikse F. Incidence of redetachment 6 months after scleral buckling surgery. Acta Ophthalmol 2010; 88(2): 199–206, https://doi.org/10.1111/j.1755-3768.2008.01425.x.
  12. Heimann H., Zou X., Jandeck C., Kellner U., Bechrakis N.E., Kreusel K.M., Helbig H., Krause L., Schüler A., Bornfeld N., Foerster M.H. Primary vitrectomy for rhegmatogenous retinal detachment: an analysis of 512 cases. Graefes Arch Clin Exp Ophthalmol 2006; 244(1): 69–78, https://doi.org/10.1007/s00417-005-0026-3.
  13. Salicone A., Smiddy W.E., Venkatraman A., Feuer W. Management of retinal detachment when no break is found. Ophthalmology 2006; 113(3): 398–403, https://doi.org/10.1016/j.ophtha.2005.10.002.
  14. Kon C.H., Asaria R.H., Occleston N.L., Khaw P.T., Aylward G.W. Risk factors for proliferative vitreoretinopathy after primary vitrectomy: a prospective study. Br J Ophthalmol 2000; 84(5): 506–511, https://doi.org/10.1136/bjo.84.5.506.
  15. Foster R.E., Meyers S.M. Recurrent retinal detachment more than 1 year after reattachment. Ophthalmology 2002; 109(10): 1821–1827, https://doi.org/10.1016/s0161-6420(02)01182-x.
  16. Miki D., Hida T., Hotta K., Shinoda K., Hirakata A. Comparison of scleral buckling and vitrectomy for retinal detachment resulting from flap tears in superior quadrants. Jpn J Ophthalmol 2001; 45(2): 187–191, https://doi.org/10.1016/s0021-5155(00)00377-4.
  17. Sharma Y.R., Karunanithi S., Azad R.V., Vohra R., Pal N., Singh D.V., Chandra P. Functional and anatomic outcome of scleral buckling versus primary vitrectomy in pseudophakic retinal detachment. Acta Ophthalmol Scand 2005; 83(3): 293–297, https://doi.org/10.1111/j.1600-0420.2005.00461.x.
  18. Yang H., Wang R., Gu Q., Zhang X. Feasibility study of chitosan as intravitreous tamponade material. Graefes Arch Clin Exp Ophthalmol 2008; 246(8): 1097–1105, https://doi.org/10.1007/s00417-008-0813-8.
  19. Lazarenko V.I., Bolshakov I.N., Ilyenkov S.S., Shatilova R.I., Kuzovnikov V.V., Chanchikov D.G., Osipova O.V., Gar’kavenko V.V., Simko I.V., Ivanov V.V. Using Bol-Hit and Kollahit-Bol grafts in ophthalmology. Rossiyskiy oftal’mologicheskiy zhurnal 2009; 2(4): 21–24.
  20. Kuzovnikov V.V., Gar’kavenko V.V., Chanchikov D.G., Osipova O.V., Ivanov V.V., Simko I.V., Lazarenko V.I., Bol’shakov I.N. Ispol’zovanie izdeliy meditsinskogo naznacheniya na osnove khitozana v oftal’mologii. V kn.: Materialy IX Mezhdunarodnoy konferentsii “Sovremennye perspektivy v issledovanii khitina i khitozana” [Use of products of medical appointment on the basis of chitosane in ophthalmology. In: Proceedings of the IX International conference “Modern perspectives in chitin and chitosan studies”]. Moscow: VNIRO Publishing; 2008; p. 181–183.
  21. Sharipova D.N. Profilaktika proliferativnoy vitreoretinopatii s ispol’zovaniem 5-ftoruratsila na gidrogelevom implantate. Dis. ... kand. med. nauk [Prevention of proliferative vitreoretinopathy with 5-fluorouracil on hydrogel implant. PhD Thesis]. Moscow; 2006.
  22. Artem’eva O.V., Samoilov A.N., Zhernakov S.V. Proliferative vitreoretinopathy: modern view on etiology and pathogenesis. Vestnik oftal’mologii 2014; 130(3): 67–71.
Baiyrkhanova A.O., Botabekova T.K., Semenova Y.M., Ismailova A.B., Rakhypbekov T.K. Physicochemical Properties of Intravitreal Implant Based on Chitosan/Polyvinyl Alcohol Saturated with 5-Fluorouracil. Sovremennye tehnologii v medicine 2017; 9(3): 102, https://doi.org/10.17691/stm2017.9.3.14


Journal in Databases

pubmed_logo.jpg

web_of_science.jpg

scopus.jpg

crossref.jpg

ebsco.jpg

embase.jpg

ulrich.jpg

cyberleninka.jpg

e-library.jpg

lan.jpg

ajd.jpg

SCImago Journal & Country Rank