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Тканеинженерные конструкты кожи и использование стволовых клеток для создания кожных эквивалентов (обзор)

Тканеинженерные конструкты кожи и использование стволовых клеток для создания кожных эквивалентов (обзор)

А.В. Мелешина, А.С. Быстрова, О.С. Роговая, Е.А. Воротеляк, А.В. Васильев, Е.В. Загайнова
Ключевые слова: биоинженерные заменители кожи; эквиваленты кожи; биоматериалы; тканевая инженерия; заживление ран; стволовые клетки.
2017, том 9, номер 1, стр. 198.
DOI: https://doi.org/10.17691/stm2017.9.1.24

Полный текст статьи

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Разработка и внедрение в клиническую практику новых биотехнологических аналогов (эквивалентов) тканей и органов, в частности эквивалентов кожи (ЭК) человека, призванных временно или постоянно заменять поврежденные или разрушенные ткани, остается актуальной задачей регенеративной медицины. В настоящее время создают и исследуют как полнослойные ЭК, так и отдельные ее слои, имеющие в своем составе живые клетки различных типов и происхождения.

Проведен сравнительный анализ существующих ЭК, как коммерческих, так и находящихся на стадии доклинических исследований, проанализированы особенности их строения и возможности использования для решения экспериментальных и клинических задач. Рассмотрены характеристики трех основных вариантов ЭК. Приведены примеры использования стволовых клеток для создания кожных эквивалентов. Описаны основные преимущества применения стволовых клеток в качестве клеточного компонента ЭК.

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Meleshina A.V., Bystrova A.S., Rogovaya O.S., Vorotelyak E.A., Vasiliev A.V., Zagaynova E.V. Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review). Sovremennye tehnologii v medicine 2017; 9(1): 198, https://doi.org/10.17691/stm2017.9.1.24


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