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Биоинженерные конструкции на основе фиброина шелка и спидроина для регенеративной медицины и тканевой инженерии (обзор)

Биоинженерные конструкции на основе фиброина шелка и спидроина для регенеративной медицины и тканевой инженерии (обзор)

О.И. Агапова
Ключевые слова: фиброин шелка; спидроин; биоинженерные конструкции; регенеративная медицина.
2017, том 9, номер 2, стр. 190.
DOI: https://doi.org/10.17691/stm2017.9.2.24

Полный текст статьи

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Представлены данные о современных разработках биоинженерных конструкций из двух уникальных биополимеров: основного белка шелка шелкопрядов (фиброина) и каркасного шелка паутины (спидроина) — и их использовании в регенеративной медицине и тканевой инженерии. Оба биополимера обладают такими важными свойствами, как биосовместимость, биодеградируемость, высокая прочность и эластичность. Доступность коконов шелкопряда в природе и отлаженные методы очистки фиброина делают этот белок весьма перспективным для применения в составе биоинженерных конструкций. Белок паутины менее распространен в природе, однако разработка альтернативных методов его получения позволяет считать спидроин многообещающим биополимером.

Рассмотрены структура и свойства фиброина шелка и спидроина, их преимущества по сравнению с другими полимерами как природного, так и синтетического происхождения, технологии изготовления биополимерных конструкций. Показано, что фиброин шелка и спидроин применяют для создания трехмерных матриксов, способствующих восстановлению поврежденных органов и тканей, биодеградируемых носителей клеток и лекарственных препаратов.

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Журнал базах данных

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SCImago Journal & Country Rank

Издание зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций.
Свидетельство о регистрации средства массовой информации ПИ № ФС 77-79187 от 16.10.2020 г.

При перепечатке ссылка на журнал обязательна.