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Механосенситивность различных клеток: возможная роль в регуляции и реализации эффектов физических методов лечения (обзор)

Механосенситивность различных клеток: возможная роль в регуляции и реализации эффектов физических методов лечения (обзор)

Ю.П. Потехина, А.И. Филатова, Е.С. Трегубова, Д.Е. Мохов
Ключевые слова: механосенситивность; механотрансдукция; механические стимулы; внеклеточный матрикс; остеопатическая манипулятивная терапия; мезенхимальные стволовые клетки.
2020, том 12, номер 4, стр. 77.
DOI: https://doi.org/10.17691/stm2020.12.4.10

Полный текст статьи

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Регуляторные сигналы в организме не ограничиваются химическими и электрическими. Есть еще один вид важных сигналов для клеток — механические (из внешней среды и возникающие в самом организме), которым незаслуженно придается меньшее значение. В обзоре обобщается новая информация о механосенситивности различных клеток соединительной ткани и нервной системы. Приводятся примеры участия механических стимулов в регуляции роста, развития, дифференцировки и функционирования тканей и органов. Основное внимание уделяется таким процессам, как ремоделирование костной ткани, заживление ран, рост нейритов, формирование нейронных сетей. Описаны механизмы механотрансдукции, участвующие в них клеточные органеллы и молекулы с механосенситивными свойствами, показана роль внеклеточного матрикса. Исследуется значение механосенситивности и механических свойств клеток в развитии некоторых патологий. Рассматривается возможная роль механосенситивности в реализации эффектов механических и мануальных методов лечения.

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