Compression Elastography in Endosonography as an Early Differential Diagnostic Technique of Liver Fibrosis Stages

The aim of the investigation was to study the capabilities of compression elastography used in endosonography to estimate the stage of fibrosis process in liver parenchyma.

Materials and Methods. We examined 67 patients with hepatic diseases including 29 patients (43.3%) with steatosis, 23 (34.3%) — with hepatitis, 15 (22.4%) — with cirrhosis. All patients underwent hepatic sonography, transient elastography, fibrogastroduodenoscopy, compression elastography in the course of endosonography. Ultrasound-assisted liver puncture was used as a reference method.

Results. The survey enabled to determine optimal threshold levels of compression elastography in steatosis, hepatitis, liver cirrhosis, when diagnostic sensitivity, specificity and accuracy of the technique are maximal. The diagnosis of hepatic steatosis is confirmed if difference coefficient is from 5 to 17 RU (F0-stage) and from 18 to 25 RU (F1-stage), hepatitis — from 26 to 37 RU (F2-stage) and from 38 to 49 RU (F3-stage), liver cirrhosis — from 50 to 100 RU (F4-stage).

Conclusion. Compression elastography in endosonography enables to image hepatic segments (segments 1, 2, 4, 5, 8), which are not always accessible in transabdominal sonography, and are inaccessible in transient elastometry; therefore, making it possible to improve early diagnostics of liver fibrosis process.

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Morozova Т.G., Borsukov А.V. Compression Elastography in Endosonography as an Early Differential Diagnostic Technique of Liver Fibrosis Stages. Sovremennye tehnologii v medicine 2014; 6(3): 79